8DNN

Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain

Summary for 8DNN

• Entry DOI: 10.2210/pdb8dnn/pdb
• Descriptor: Spike protein S1, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ... (4 entities in total)
• Functional Keywords: sars-cov-2, antibody, viral glycoprotein, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 6
• Total formula weight: 148722.43

Authors

Muthuraman, K.,Kucharska, I.,Ivanochko, D.,Julien, J.P. (deposition date: 2022-07-11, release date: 2023-05-24, Last modification date: 2023-12-06)

• Primary citation: Burn Aschner, C.,Muthuraman, K.,Kucharska, I.,Cui, H.,Prieto, K.,Nair, M.S.,Wang, M.,Huang, Y.,Christie-Holmes, N.,Poon, B.,Lam, J.,Sultana, A.,Kozak, R.,Mubareka, S.,Rubinstein, J.L.,Rujas, E.,Treanor, B.,Ho, D.D.,Jetha, A.,Julien, J.P.; A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.; Sci Transl Med, 15:eadf4549-eadf4549, 2023; PubMed: 37224226; DOI: 10.1126/scitranslmed.adf4549

Experimental method

X-RAY DIFFRACTION (3.12 Å)