7UXL

Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29

Summary for 7UXL

Entry DOI	10.2210/pdb7uxl/pdb
Descriptor	RUPA-44 Fab Kappa chain, RUPA-44 Fab Heavy chain, Gametocyte surface protein P45/48, ... (6 entities in total)
Functional Keywords	pfs48/45, human transmission-blocking antibodies, plasmodium falciparum, malaria, immune system
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	111470.65
Authors	Hailemariam, S.,Ivanochko, D.,Julien, J.P. (deposition date: 2022-05-05, release date: 2023-02-15, Last modification date: 2023-10-25)
Primary citation	Fabra-Garcia, A.,Hailemariam, S.,de Jong, R.M.,Janssen, K.,Teelen, K.,van de Vegte-Bolmer, M.,van Gemert, G.J.,Ivanochko, D.,Semesi, A.,McLeod, B.,Vos, M.W.,de Bruijni, M.H.C.,Bolscher, J.M.,Szabat, M.,Vogt, S.,Kraft, L.,Duncan, S.,Kamya, M.R.,Feeney, M.E.,Jagannathan, P.,Greenhouse, B.,Dechering, K.J.,Sauerwein, R.W.,King, C.R.,MacGill, R.S.,Bousema, T.,Julien, J.P.,Jore, M.M. Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes. Immunity, 56:406-419.e7, 2023 Cited by PubMed: 36792574 DOI: 10.1016/j.immuni.2023.01.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation