7UXL
Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | RUPA-44 Fab Kappa chain | polymer | 214 | 23483.1 | 1 | Homo sapiens | ||
| 2 | B (F) | RUPA-44 Fab Heavy chain | polymer | 230 | 24277.3 | 1 | Homo sapiens | ||
| 3 | C (R) | Gametocyte surface protein P45/48 | polymer | 147 | 16515.4 | 1 | UniProt (Q8I6T1) Pfam (PF07422) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 4 | D (A) | RUPA-29 Fab Heavy chain | polymer | 223 | 23912.0 | 1 | Homo sapiens | ||
| 5 | E (B) | RUPA-29 Fab Lambda chain | polymer | 216 | 23061.5 | 1 | Homo sapiens | ||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
R: 291 - 428 (UniProt: Q8I6T1)
| PDB | External Database | Details |
|---|---|---|
| Tyr 308 | His 308 | engineered mutation |
| Leu 397 | Gly 397 | engineered mutation |
| Val 402 | Ile 402 | engineered mutation |
| Gly 429 | - | expression tag |
| Thr 430 | - | expression tag |
| Lys 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 111249.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 111470.6 |
