4V94
 
 | | Molecular architecture of the eukaryotic chaperonin TRiC/CCT derived by a combination of chemical crosslinking and mass-spectrometry, XL-MS | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Leitner, A, Joachimiak, L.A, Bracher, A, Walzthoeni, T, Chen, B, Monkemeyer, L, Pechmann, S, Holmes, S, Cong, Y, Ma, B, Ludtke, S, Chiu, W, Hartl, F.U, Aebersold, R, Frydman, J. | | 登録日 | 2012-01-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT.
Structure, 20, 2012
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4V05
 | | FGFR1 in complex with AZD4547. | | 分子名称: | 1,2-ETHANEDIOL, FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ... | | 著者 | Tucker, J, Klein, T, Breed, J, Breeze, A, Overman, R, Phillips, C, Norman, R.A. | | 登録日 | 2014-09-10 | | 公開日 | 2014-12-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4
Structure, 22, 2014
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4UX6
 | | The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, INDUCIBLE, ... | | 著者 | Cheshire, D.R, Andrews, G, Beaton, H.G, Birkinshaw, T, Boughton-Smith, N, Connolly, S, Cook, T.R, Cooper, A, Cooper, S.L, Cox, D, Dixon, J, Gensmantel, N, Hamley, P.J, Harrison, R, Hartopp, P, Kack, H, Luker, T, Mete, A, Millichip, I, Nicholls, D.J, Pimm, A.D, St-Gallay, S.A, Wallace, A.V. | | 登録日 | 2014-08-19 | | 公開日 | 2014-10-08 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).
Bioorg.Med.Chem.Lett., 21, 2011
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4UXQ
 | | FGFR4 in complex with Ponatinib | | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, FIBROBLAST GROWTH FACTOR RECEPTOR 4, SULFATE ION | | 著者 | Tucker, J, Klein, T, Breed, J, Breeze, A, Overman, R, Phillips, C, Norman, R.A. | | 登録日 | 2014-08-27 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4
Structure, 22, 2014
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1D9Q
 | | OXIDIZED PEA FRUCTOSE-1,6-BISPHOSPHATASE FORM 1 | | 分子名称: | FRUCTOSE-1,6-BISPHOSPHATASE | | 著者 | Chiadmi, M, Navaza, A, Miginiac-Maslow, M, Jacquot, J.-P, Cherfils, J. | | 登録日 | 1999-10-29 | | 公開日 | 1999-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Redox signalling in the chloroplast: structure of oxidized pea fructose-1,6-bisphosphate phosphatase.
EMBO J., 18, 1999
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1DBZ
 | | C153S MUTANT OF PEA FRUCTOSE-1,6-BISPHOSPHATASE | | 分子名称: | FRUCTOSE-1,6-BISPHOSPHATASE | | 著者 | Chiadmi, M, Navaza, A, Miginiac-Maslow, M, Jacquot, J.P, Cherfils, J. | | 登録日 | 1999-11-03 | | 公開日 | 1999-12-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Redox signalling in the chloroplast: structure of oxidized pea fructose-1,6-bisphosphate phosphatase.
EMBO J., 18, 1999
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1DSE
 | | CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX, WITH PHOSPHATE BOUND, PH 6, 100K | | 分子名称: | CYTOCHROME C PEROXIDASE, IMIDAZOLE, PHOSPHATE ION, ... | | 著者 | Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B. | | 登録日 | 2000-01-07 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
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1DSO
 | | CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 6, ROOM TEMPERATURE. | | 分子名称: | CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B. | | 登録日 | 2000-01-07 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
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1DRE
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1DQ9
 | | COMPLEX OF CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG-COA | | 分子名称: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, PROTEIN (HMG-COA REDUCTASE) | | 著者 | Istvan, E.S, Palnitkar, M, Buchanan, S.K, Deisenhofer, J. | | 登録日 | 1999-12-30 | | 公開日 | 2000-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J., 19, 2000
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1DY4
 | | CBH1 IN COMPLEX WITH S-PROPRANOLOL | | 分子名称: | 1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, ... | | 著者 | Stahlberg, J, Henriksson, H, Divne, C, Isaksson, R, Pettersson, G, Johansson, G, Jones, T.A. | | 登録日 | 2000-01-26 | | 公開日 | 2000-12-18 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis for Enantiomer Binding and Separation of a Common Beta-Blocker: Crystal Structure of Cellobiohydrolase Cel7A with Bound (S)-Propranolol at 1.9 A Resolution
J.Mol.Biol., 305, 2001
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1E4F
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1DQA
 | | COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+ | | 分子名称: | 3-HYDROXY-3-METHYL-GLUTARIC ACID, COENZYME A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Istvan, E.S, Palnitkar, M, Buchanan, S.K, Deisenhofer, J. | | 登録日 | 1999-12-30 | | 公開日 | 2000-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J., 19, 2000
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1E09
 | | Solution Structure of the Major Cherry Allergen Pru av 1 | | 分子名称: | PRU AV 1 | | 著者 | Neudecker, P, Nerkamp, J, Schweimer, K, Sticht, H, Boehm, M, Scheurer, S, Vieths, S, Roesch, P. | | 登録日 | 2000-03-15 | | 公開日 | 2001-03-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Allergic Cross-Reactivity Made Visible: The Solution Structure of the Major Cherry Allergen Pru Av 1
J.Biol.Chem., 276, 2001
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1DMU
 | | Crystal structure of the restriction endonuclease BglI (e.c.3.1.21.4) bound to its dna recognition sequence | | 分子名称: | BETA-MERCAPTOETHANOL, BGLI RESTRICTION ENDONUCLEASE, CALCIUM ION, ... | | 著者 | Newman, M, Lunnen, K, Wilson, G, Greci, J, Schildkraut, I, Phillips, S.E.V. | | 登録日 | 1999-12-15 | | 公開日 | 1999-12-18 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of restriction endonuclease BglI bound to its interrupted DNA recognition sequence.
EMBO J., 17, 1998
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1DS4
 | | CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX, PH 6, 100K | | 分子名称: | CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B. | | 登録日 | 2000-01-07 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
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1DSP
 | | CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 7, ROOM TEMPERATURE. | | 分子名称: | CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B. | | 登録日 | 2000-01-07 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
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1DQ8
 | | COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-HYDROXY-3-METHYL-GLUTARIC ACID, COENZYME A, ... | | 著者 | Istvan, E.S, Palnitkar, M, Buchanan, S.K, Deisenhofer, J. | | 登録日 | 1999-12-30 | | 公開日 | 2000-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J., 19, 2000
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1DSG
 | | CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 5, ROOM TEMPERATURE. | | 分子名称: | CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B. | | 登録日 | 2000-01-07 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
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1E1A
 | | Crystal structure of DFPase from Loligo vulgaris | | 分子名称: | CALCIUM ION, DIISOPROPYLFLUOROPHOSPHATASE | | 著者 | Koepke, J, Scharff, E.I, Fritzsch, G, Luecke, C, Rueterjans, H. | | 登録日 | 2000-04-28 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of Diisopropylfluorophosphatase from Loligo Vulgaris
Structure, 9, 2001
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1E4G
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1DSB
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1DLO
 | | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | | 分子名称: | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE | | 著者 | Hsiou, Y, Ding, J, Das, K, Hughes, S, Arnold, E. | | 登録日 | 1996-04-17 | | 公開日 | 1996-08-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.
Structure, 4, 1996
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1E9A
 | | Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A | | 分子名称: | MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE | | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | | 登録日 | 2000-10-10 | | 公開日 | 2001-10-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
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1EGN
 | | CELLOBIOHYDROLASE CEL7A (E223S, A224H, L225V, T226A, D262G) MUTANT | | 分子名称: | 1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE CEL7A, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION | | 著者 | Stahlberg, J, Harris, M, Jones, T.A. | | 登録日 | 2000-02-16 | | 公開日 | 2001-05-16 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Engineering of a glycosidase Family 7 cellobiohydrolase to more alkaline pH optimum: the pH behaviour of Trichoderma reesei Cel7A and its E223S/ A224H/L225V/T226A/D262G mutant.
Biochem.J., 356, 2001
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