1DQ8

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA

Summary for 1DQ8

Entry DOI	10.2210/pdb1dq8/pdb
Descriptor	PROTEIN (HMG-COA REDUCTASE), COENZYME A, 3-HYDROXY-3-METHYL-GLUTARIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	204113.29
Authors	Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J. (deposition date: 1999-12-30, release date: 2000-03-08, Last modification date: 2024-02-07)
Primary citation	Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J., 19:819-830, 2000 Cited by PubMed: 10698924 DOI: 10.1093/emboj/19.5.819 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation