1DQ9

COMPLEX OF CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG-COA

Summary for 1DQ9

DescriptorPROTEIN (HMG-COA REDUCTASE), 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A (2 entities in total)
Functional Keywordsoxidoreductase, cholesterol biosynthesis, hmg-coa, nadph
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein P04035
Total number of polymer chains4
Total molecular weight203712.57
Authors
Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J. (deposition date: 1999-12-30, release date: 2000-03-08, Last modification date: 2018-03-14)
Primary citation
Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J.
Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J., 19:819-830, 2000
PubMed: 10698924 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/19.5.819
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers302.8%5.8%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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