4UXQ

FGFR4 in complex with Ponatinib

Summary for 4UXQ

Entry DOI	10.2210/pdb4uxq/pdb
Related	4V01 4V04 4V05
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 4, SULFATE ION, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, ... (4 entities in total)
Functional Keywords	transferase, kinase dfg-out fgfr inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455
Total number of polymer chains	1
Total formula weight	35083.35
Authors	Tucker, J.,Klein, T.,Breed, J.,Breeze, A.,Overman, R.,Phillips, C.,Norman, R.A. (deposition date: 2014-08-27, release date: 2014-12-03, Last modification date: 2014-12-17)
Primary citation	Tucker, J.A.,Klein, T.,Breed, J.,Breeze, A.L.,Overman, R.,Phillips, C.,Norman, R.A. Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4 Structure, 22:1764-, 2014 Cited by PubMed: 25465127 DOI: 10.1016/J.STR.2014.09.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation