4UXQ
FGFR4 in complex with Ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | FIBROBLAST GROWTH FACTOR RECEPTOR 4 | polymer | 309 | 34454.7 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | FGFR-4, FGFR4, CD334 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 1 | Chemie (0LI) | |||
| 4 | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A: 447 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 445 | - | expression tag |
| Ser 446 | - | expression tag |
| Ala 477 | Cys 477 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34454.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 628.6 | |
| All* | Total formula weight | 35083.3 |
