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4V01

FGFR1 in complex with ponatinib (co-crystallisation).

Summary for 4V01
Entry DOI10.2210/pdb4v01/pdb
Related4UXQ 4V04 4V05
DescriptorFIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight72532.86
Authors
Tucker, J.,Klein, T.,Breed, J.,Breeze, A.,Overman, R.,Phillips, C.,Norman, R.A. (deposition date: 2014-09-10, release date: 2014-12-10, Last modification date: 2018-04-04)
Primary citationTucker, J.A.,Klein, T.,Breed, J.,Breeze, A.L.,Overman, R.,Phillips, C.,Norman, R.A.
Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4
Structure, 22:1764-, 2014
Cited by
PubMed: 25465127
DOI: 10.1016/J.STR.2014.09.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

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