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4V05

FGFR1 in complex with AZD4547.

Summary for 4V05
Entry DOI10.2210/pdb4v05/pdb
Related4UXQ 4V01 4V04
DescriptorFIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B, 1,2-ETHANEDIOL, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide, ... (5 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight71892.42
Authors
Tucker, J.,Klein, T.,Breed, J.,Breeze, A.,Overman, R.,Phillips, C.,Norman, R.A. (deposition date: 2014-09-10, release date: 2014-12-10, Last modification date: 2014-12-17)
Primary citationTucker, J.A.,Klein, T.,Breed, J.,Breeze, A.L.,Overman, R.,Phillips, C.,Norman, R.A.
Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4
Structure, 22:1764-, 2014
Cited by
PubMed: 25465127
DOI: 10.1016/J.STR.2014.09.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.57 Å)
Structure validation

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