4V01

FGFR1 in complex with ponatinib (co-crystallisation).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1764

Chain	Residue
B	ARG570
B	ARG627
B	THR657
B	ASN659
B	ARG661
B	HOH2063

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1766

Chain	Residue
A	LEU473
A	LEU500
A	LEU548
A	GLY549
A	ARG470
A	TRP471
A	GLU472

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1765

Chain	Residue
B	SER597
B	VAL601
B	PHE694
B	ASN724
B	CYS725
B	THR726
B	LEU729

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1767

Chain	Residue
A	SER597
A	PHE694
A	ASN724
A	CYS725
A	THR726
A	LEU729

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1768

Chain	Residue
A	GLY539
A	LYS540
A	LYS618
A	HOH2032
A	HOH2161

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1769

Chain	Residue
A	ARG470
A	LYS618
A	HIS679
A	EDO1774
A	HOH2162

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 1766

Chain	Residue
B	ALA575

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1770

Chain	Residue
A	ARG470
A	GLU533
A	LYS618
A	CYS619
A	ILE620

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1771

Chain	Residue
A	TRP684
A	VAL688
A	TYR701
A	ARG718
A	MET719
A	TRP737
A	HOH2085

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 1767

Chain	Residue
B	TRP684
B	TYR701
B	LEU713
B	ARG718
B	MET719
B	TRP737
B	HOH2073

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1768

Chain	Residue
B	PRO466
B	ILE529
B	MET532
B	GLU533
B	LYS536
B	THR552

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1772

Chain	Residue
A	THR746
A	PHE747
A	LYS748
A	HOH2097

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1773

Chain	Residue
A	LYS656
A	GLY703
A	VAL704
A	PRO705
A	HOH2116
B	GLU708

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1774

Chain	Residue
A	ARG470
A	TRP471
A	SO41769

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1775

Chain	Residue
A	TYR572
A	LEU595
A	SER602
A	CYS603
A	GLN606
A	ASN635

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1769

Chain	Residue
B	MET535
B	GLY539
B	ILE544
B	ILE545
B	ASN546
B	LEU547

---

site_id	BC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0LI A 1776

Chain	Residue
A	LEU614
A	ILE620
A	HIS621
A	LEU630
A	ILE639
A	ALA640
A	ASP641
A	LEU484
A	ALA512
A	LYS514
A	GLU531
A	MET534
A	MET535
A	ILE538
A	ILE545
A	VAL561
A	GLU562
A	TYR563
A	ALA564

---

site_id	BC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0LI B 1770

Chain	Residue
B	ALA512
B	LYS514
B	GLU531
B	MET534
B	ILE545
B	VAL559
B	VAL561
B	GLU562
B	TYR563
B	ALA564
B	LEU614
B	CYS619
B	ILE620
B	HIS621
B	LEU630
B	ILE639
B	ALA640
B	ASP641
B	PHE642

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---