4V04

FGFR1 in complex with ponatinib.

Summary for 4V04

Entry DOI	10.2210/pdb4v04/pdb
Related	4UXQ 4V01 4V05
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B, 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, ... (5 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	72498.86
Authors	Tucker, J.,Klein, T.,Breed, J.,Breeze, A.,Overman, R.,Phillips, C.,Norman, R.A. (deposition date: 2014-09-10, release date: 2014-12-10, Last modification date: 2024-05-08)
Primary citation	Tucker, J.A.,Klein, T.,Breed, J.,Breeze, A.L.,Overman, R.,Phillips, C.,Norman, R.A. Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4 Structure, 22:1764-, 2014 Cited by PubMed: 25465127 DOI: 10.1016/J.STR.2014.09.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation