4V04
FGFR1 in complex with ponatinib.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | ROTATING ANODE |
| Source details | RIGAKU FR-E |
| Temperature [K] | 100 |
| Detector technology | CCD |
| Detector | RIGAKU CCD |
| Spacegroup name | C 1 2 1 |
| Unit cell lengths | 207.255, 58.090, 65.231 |
| Unit cell angles | 90.00, 107.38, 90.00 |
Refinement procedure
| Resolution | 21.370 - 2.120 |
| R-factor | 0.1881 |
| Rwork | 0.186 |
| R-free | 0.22800 |
| Structure solution method | OTHER |
| Starting model (for MR) | NONE |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.050 |
| Refinement software | BUSTER (2.11.5) |
Data quality characteristics
| Overall | |
| Low resolution limit [Å] | 98.000 |
| High resolution limit [Å] | 2.120 |
| Rmerge | 0.040 |
| Number of reflections | 41149 |
| Completeness [%] | 97.0 |
| Redundancy | 3.5 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | 18-20% (W/V) PEG 8000, 200MM AMMONIUM SULPHATE, 100MM PCTP PH6.75, 20% (V/V) ETHYLENE GLYCOL |
