6LNI
| Cryo-EM structure of amyloid fibril formed by full-length human prion protein | Descriptor: | Major prion protein | Authors: | Wang, L.Q, Zhao, K, Yuan, H.Y, Wang, Q, Guan, Z.Y, Tao, J, Li, X.N, Hao, M.M, Chen, J, Zhang, D.L, Zhu, H.L, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2019-12-30 | Release date: | 2020-06-10 | Last modified: | 2020-06-24 | Method: | ELECTRON MICROSCOPY (2.702 Å) | Cite: | Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nat.Struct.Mol.Biol., 27, 2020
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7CJL
| Metallo-Beta-Lactamase VIM-2 in complex with (S)-N-(3-(2H-tetrazol-5-yl)phenyl)-3-mercapto-2-methylpropanamide | Descriptor: | (S)-N-(3-(2H-tetrazol-5-yl)phenyl)-3-mercapto-2-methylpropanamide, Beta-lactamase class B VIM-2, FORMIC ACID, ... | Authors: | Yan, Y.-H, Chen, J, Zhan, Z, Yu, Z.-J, Li, G, Li, G.-B, Guo, L, Wu, Y. | Deposit date: | 2020-07-11 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.789 Å) | Cite: | Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-beta-lactamase inhibitors. Rsc Adv, 10, 2020
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7DWV
| Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation E196K | Descriptor: | Major prion protein | Authors: | Wang, L.Q, Zhao, K, Yuan, H.Y, Li, X.N, Dang, H.B, Ma, Y.Y, Wang, Q, Wang, C, Sun, Y.P, Chen, J, Li, D, Zhang, D.L, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2021-01-18 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Sci Adv, 7, 2021
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5ZN8
| Crystal structure of nicotinamidase PncA from Bacillus subtilis | Descriptor: | Isochorismatase, ZINC ION | Authors: | Shang, F, Chen, J, Wang, L, Xu, Y. | Deposit date: | 2018-04-08 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis. Biochem.Biophys.Res.Commun., 503, 2018
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6A8L
| Crystal structure of nicotinamidase/ pyrazinamidase PncA from Bacillus subtilis | Descriptor: | Isochorismatase, ZINC ION | Authors: | Shang, F, Chen, J, Wang, L, Xu, Y. | Deposit date: | 2018-07-09 | Release date: | 2018-08-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis. Biochem. Biophys. Res. Commun., 503, 2018
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6BZO
| Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA | Descriptor: | DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. | Deposit date: | 2017-12-25 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
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6BHU
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6C0V
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6C3P
| Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | Deposit date: | 2018-01-10 | Release date: | 2018-01-24 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
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6C3O
| Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | Deposit date: | 2018-01-10 | Release date: | 2018-01-31 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of human KATP in complex with ATP and ADP Elife, 6, 2017
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7YDL
| Crystal structure of the P450 BM3 heme domain mutant F87A/T268I/A184V/A82T in complex with N-imidazolyl-hexanoyl-L-phenylalanine | Descriptor: | (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y. | Deposit date: | 2022-07-04 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of the P450 BM3 heme domain mutant F87A/T268I/A184V/A82T in complex with N-imidazolyl-hexanoyl-L-phenylalanine To Be Published
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6M7J
| Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin | Descriptor: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. | Deposit date: | 2018-08-20 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
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6MSM
| Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | Authors: | Zhang, Z, Liu, F, Chen, J. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular structure of the ATP-bound, phosphorylated human CFTR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2OJU
| X-ray structure of complex of human cyclophilin J with cyclosporin A | Descriptor: | CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3 | Authors: | Xia, Z, Huang, L. | Deposit date: | 2007-01-14 | Release date: | 2008-01-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Targeting Cyclophilin J, a Novel Peptidyl-Prolyl Isomerase, Can Induce Cellular G1/S Arrest and Repress the Growth of Hepatocellular Carcinoma To be Published
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2OK3
| X-ray structure of human cyclophilin J at 2.0 angstrom | Descriptor: | NICKEL (II) ION, Peptidyl-prolyl cis-trans isomerase-like 3 | Authors: | Xia, Z. | Deposit date: | 2007-01-15 | Release date: | 2008-01-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Targeting Cyclophilin J, a novel peptidyl-prolyl isomerase, can induce cellular G1/S arrest and repress the growth of Hepatocellular carcinoma To be Published
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2O7Y
| Duplex DNA containing an abasic site with an opposite T (alpha anomer) in 5'-G_AC-3' (10 structure ensemble and averaged structure) | Descriptor: | 5'-D(*CP*CP*AP*AP*AP*GP*(ORP)P*AP*CP*CP*GP*GP*G)-3', 5'-D(*CP*CP*CP*GP*GP*TP*TP*CP*TP*TP*TP*GP*G)-3' | Authors: | Dupradeau, F.Y, Case, D.A, Turner, C.J, Stubbe, J. | Deposit date: | 2006-12-11 | Release date: | 2007-11-27 | Last modified: | 2023-11-29 | Method: | SOLUTION NMR | Cite: | DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics. Nucleic Acids Res., 36, 2008
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3ED0
| Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with emodin | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, BENZAMIDINE, ... | Authors: | Zhang, L, Zhang, H, Liu, W, Guo, Y, Shen, X, Jiang, H. | Deposit date: | 2008-09-02 | Release date: | 2009-07-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization BMC MICROBIOL., 9, 2009
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7WZ5
| Larimichthys crocea IFNi | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon C | Authors: | Chen, J.J. | Deposit date: | 2022-02-17 | Release date: | 2023-02-08 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Molecular and Structural Basis of Receptor Binding and Signaling of a Fish Type I IFN with Three Disulfide Bonds. J Immunol., 209, 2022
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3CYY
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7M10
| PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1 | Descriptor: | FORMIC ACID, Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2021-03-11 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem.J., 478, 2021
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7DR6
| PA28alpha-beta in complex with immunoproteasome | Descriptor: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | Authors: | Cong, Y, Xu, C. | Deposit date: | 2020-12-26 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
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7DR7
| bovine 20S immunoproteasome | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | Authors: | Xu, C, Cong, Y. | Deposit date: | 2020-12-26 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
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7DRW
| Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators | Descriptor: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | Authors: | Cong, Y, Xu, C. | Deposit date: | 2020-12-29 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
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6IIJ
| Cryo-EM structure of CV-A10 mature virion | Descriptor: | SPHINGOSINE, VP1, VP2, ... | Authors: | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | Deposit date: | 2018-10-06 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses. Cell Discov, 5, 2019
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6IIO
| Cryo-EM structure of CV-A10 native empty particle | Descriptor: | VP0, VP1, VP3 | Authors: | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | Deposit date: | 2018-10-07 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses. Cell Discov, 5, 2019
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