4PM4
| Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv | 分子名称: | CHLORIDE ION, Iron complex transporter substrate-binding protein, SULFATE ION | 著者 | Arbing, M.A, Chan, S, Tran, N, Kuo, E, Lu, J, Harris, L.R, Zhou, T.T, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2014-05-20 | 公開日 | 2014-06-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv To Be Published
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5M7R
| Structure of human O-GlcNAc hydrolase | 分子名称: | Protein O-GlcNAcase | 著者 | Roth, C, Chan, S, Offen, W.A, Hemsworth, G.R, Willems, L.I, King, D, Varghese, V, Britton, R, Vocadlo, D.J, Davies, G.J. | 登録日 | 2016-10-28 | 公開日 | 2017-03-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13, 2017
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5M7T
| Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor | 分子名称: | (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, Protein O-GlcNAcase | 著者 | Roth, C, Chan, S, Offen, W.A, Hemsworth, G.R, Willems, L.I, King, D, Varghese, V, Britton, R, Vocadlo, D.J, Davies, G.J. | 登録日 | 2016-10-28 | 公開日 | 2017-03-29 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13, 2017
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5M7S
| Structure of human O-GlcNAc hydrolase with bound transition state analog ThiametG | 分子名称: | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, Protein O-GlcNAcase | 著者 | Roth, C, Chan, S, Offen, W.A, Hemsworth, G.R, Willems, L.I, King, D, Varghese, V, Britton, R, Vocadlo, D.J, Davies, G.J. | 登録日 | 2016-10-28 | 公開日 | 2017-03-29 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13, 2017
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5M7U
| Structure of human O-GlcNAc hydrolase with new iminocyclitol type inhibitor | 分子名称: | 2-[(2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-[3-[3-(trifluoromethyl)phenyl]propyl]pyrrolidin-2-yl]-~{N}-methyl-ethanamide, Protein O-GlcNAcase | 著者 | Roth, C, Chan, S, Offen, W.A, Hemsworth, G.R, Willems, L.I, King, D, Varghese, V, Britton, R, Vocadlo, D.J, Davies, G.J. | 登録日 | 2016-10-28 | 公開日 | 2017-03-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13, 2017
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5CYU
| Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system. | 分子名称: | Conserved membrane protein | 著者 | Arbing, M.A, Chan, S, Kahng, S, Kim, J, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2015-07-30 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. Bmc Struct.Biol., 16, 2016
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2GM8
| TenA Homolog/Thi-4 Thiaminase complexed with product 4-amino-5-hydroxymethyl-2-methylpyrimidine | 分子名称: | 1,2-ETHANEDIOL, 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE, tenA homolog/Thi-4 Thiaminase | 著者 | Sawaya, M.R, Chan, S, Han, G.W, Perry, L.J, Pashkov, I. | 登録日 | 2006-04-06 | 公開日 | 2006-04-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of a TenA Homolog/Thi-4 Thiaminase from Pyrobaculum Aerophilum To be Published
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2GM7
| TenA Homolog/Thi-4 Thiaminase from Pyrobaculum Aerophilum | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, PHOSPHATE ION, ... | 著者 | Sawaya, M.R, Chan, S, Han, G.W, Perry, L.J. | 登録日 | 2006-04-06 | 公開日 | 2006-04-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of a Ten A Homolog/Thi-4 Thiaminase from Pyrobaculum Aerophilum To be Published
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3OGI
| Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c) | 分子名称: | Putative ESAT-6-like protein 6, Putative ESAT-6-like protein 7 | 著者 | Arbing, M.A, Chan, S, Zhou, T.T, Ahn, C, Harris, L, Kuo, E, Sawaya, M.R, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | 登録日 | 2010-08-16 | 公開日 | 2010-08-25 | 最終更新日 | 2014-05-21 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One, 8, 2013
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1RII
| Crystal structure of phosphoglycerate mutase from M. Tuberculosis | 分子名称: | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, GLYCEROL | 著者 | Mueller, P, Sawaya, M.R, Chan, S, Wu, Y, Pashkova, I, Perry, J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-11-17 | 公開日 | 2004-10-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. Acta Crystallogr.,Sect.D, 61, 2005
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1SGV
| STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB) | 分子名称: | tRNA pseudouridine synthase B | 著者 | Chaudhuri, B.N, Chan, S, Perry, L.J, Yeates, T.O, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2004-02-24 | 公開日 | 2004-03-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft. J.Biol.Chem., 279, 2004
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4GZR
| Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP (Rv2346c-Rv2347c) complex in space group C2221 | 分子名称: | ESAT-6-like protein 6, ESAT-6-like protein 7, SULFATE ION | 著者 | Arbing, M.A, Chan, S, He, Q, Harris, L, Zhou, T.T, Kuo, E, Ahn, C.J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI) | 登録日 | 2012-09-06 | 公開日 | 2012-09-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.553 Å) | 主引用文献 | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One, 8, 2013
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4I0X
| Crystal structure of the Mycobacterum abscessus EsxEF (Mab_3112-Mab_3113) complex | 分子名称: | BETA-MERCAPTOETHANOL, ESAT-6-like protein MAB_3112, ESAT-6-like protein MAB_3113, ... | 著者 | Arbing, M.A, Chan, S, Lu, J, Kuo, E, Harris, L, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | 登録日 | 2012-11-19 | 公開日 | 2013-01-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.956 Å) | 主引用文献 | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One, 8, 2013
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5ABG
| Structure of GH84 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-[(2R,3S,4R,5R)-1-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION, ... | 著者 | Bergeron-Brlek, M, Goodwin-Tindall, J, Cekic, N, Varghese, V, Zandberg, W.F, Shan, X, Roth, C, Chan, S, Davies, G.J, Vocadlo, D.J, Britton, R. | 登録日 | 2015-08-05 | 公開日 | 2015-11-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors. Angew.Chem.Int.Ed.Engl., 54, 2015
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5ABF
| Structure of GH84 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-[(2S,3R,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION, ... | 著者 | Bergeron-Brlek, M, Goodwin-Tindall, J, Cekic, N, Varghese, V, Zandberg, W.F, Shan, X, Roth, C, Chan, S, Davies, G.J, Vocadlo, D.J, Britton, R. | 登録日 | 2015-08-05 | 公開日 | 2015-11-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors. Angew.Chem.Int.Ed.Engl., 54, 2015
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5ABE
| Structure of GH84 with ligand | 分子名称: | 2-[(2S,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION, O-GLCNACASE BT_4395 | 著者 | Bergeron-Brlek, M, Goodwin-Tindall, J, Cekic, N, Varghese, V, Zandberg, W.F, Shan, X, Roth, C, Chan, S, Davies, G.J, Vocadlo, D.J, Britton, R. | 登録日 | 2015-08-05 | 公開日 | 2015-11-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors. Angew.Chem.Int.Ed.Engl., 54, 2015
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5ABH
| Structure of GH84 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-[(2R,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION, ... | 著者 | Bergeron-Brlek, M, Goodwin-Tindall, J, Cekic, N, Varghese, V, Zandberg, W.F, Shan, X, Roth, C, Chan, S, Davies, G.J, Vocadlo, D.J, Britton, R. | 登録日 | 2015-08-05 | 公開日 | 2015-11-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors. Angew.Chem.Int.Ed.Engl., 54, 2015
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7LAW
| crystal structure of GITR complex with GITR-L | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | 著者 | Longenecker, K.L, Rogers, B, Bigelow, L, Judge, R.A, Alvarez, H. | 登録日 | 2021-01-07 | 公開日 | 2022-03-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.752 Å) | 主引用文献 | An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy. Nat Cancer, 3, 2022
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2JRK
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8UR7
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8UR5
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6NRE
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6EYF
| Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cholinesterase, GLYCEROL, ... | 著者 | Brazzolotto, X, De la Mora, E, Dighe, S, Ross, B. | 登録日 | 2017-11-12 | 公開日 | 2018-11-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model Commun Chem, 2019
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4RZT
| Lac repressor engineered to bind sucralose, sucralose-bound tetramer | 分子名称: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Lac repressor | 著者 | Arbing, M.A, Cascio, D, Sawaya, M.R, Kosuri, S, Church, G.M. | 登録日 | 2014-12-24 | 公開日 | 2015-12-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Engineering an allosteric transcription factor to respond to new ligands. Nat.Methods, 13, 2016
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4RZS
| Lac repressor engineered to bind sucralose, unliganded tetramer | 分子名称: | GLYCEROL, Lac repressor | 著者 | Arbing, M.A, Cascio, D, Kosuri, S, Church, G.M. | 登録日 | 2014-12-24 | 公開日 | 2015-12-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Engineering an allosteric transcription factor to respond to new ligands. Nat.Methods, 13, 2016
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