5CYU

Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system.

Summary for 5CYU

Entry DOI	10.2210/pdb5cyu/pdb
Descriptor	Conserved membrane protein (2 entities in total)
Functional Keywords	membrane protein, virulence, protein secretion, mycobacteria, structural genomics, psi-2, protein structure initiative, tb structural genomics consortium, tbsgc
Biological source	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Total number of polymer chains	1
Total formula weight	42997.34
Authors	Arbing, M.A.,Chan, S.,Kahng, S.,Kim, J.,Eisenberg, D.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-07-30, release date: 2015-08-12, Last modification date: 2024-10-30)
Primary citation	Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. Bmc Struct.Biol., 16:5-5, 2016 Cited by PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system. PubMed: 26922638 DOI: 10.1186/s12900-016-0056-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.07 Å)

Structure validation