5ABE

Structure of GH84 with ligand

Summary for 5ABE

• Entry DOI: 10.2210/pdb5abe/pdb
• Related: 5ABF 5ABG 5ABH
• Descriptor: O-GLCNACASE BT_4395, 2-[(2S,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase, tim-barrel, inhibitor
• Biological source: BACTEROIDES THETAIOTAOMICRON
• Total number of polymer chains: 2
• Total formula weight: 167603.59

Authors

Bergeron-Brlek, M.,Goodwin-Tindall, J.,Cekic, N.,Varghese, V.,Zandberg, W.F.,Shan, X.,Roth, C.,Chan, S.,Davies, G.J.,Vocadlo, D.J.,Britton, R. (deposition date: 2015-08-05, release date: 2015-11-18, Last modification date: 2024-05-08)

• Primary citation: Bergeron-Brlek, M.,Goodwin-Tindall, J.,Cekic, N.,Roth, C.,Zandberg, W.F.,Shan, X.,Varghese, V.,Chan, S.,Davies, G.J.,Vocadlo, D.J.,Britton, R.; A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.; Angew.Chem.Int.Ed.Engl., 54:15429-, 2015; PubMed: 26545827; DOI: 10.1002/ANIE.201507985

Experimental method

X-RAY DIFFRACTION (2 Å)