2XDY
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5MZ6
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![BU of 5mz6 by Molmil](/molmil-images/mine/5mz6) | Cryo-EM structure of a Separase-Securin complex from Caenorhabditis elegans at 3.8 A resolution | Descriptor: | Interactor of FizzY protein, SEParase | Authors: | Boland, A, Martin, T.G, Zhang, Z, Yang, J, Bai, X.C, Chang, L, Scheres, S.H.W, Barford, D. | Deposit date: | 2017-01-31 | Release date: | 2017-03-08 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. Nat. Struct. Mol. Biol., 24, 2017
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2YHB
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2YHA
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![BU of 2yha by Molmil](/molmil-images/mine/2yha) | |
4C0G
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![BU of 4c0g by Molmil](/molmil-images/mine/4c0g) | Structure of the NOT-box domain of human CNOT3 | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 | Authors: | Boland, A, Chen, Y, Raisch, T, Jonas, S, Izaurralde, E, Weichenrieder, O. | Deposit date: | 2013-08-01 | Release date: | 2013-10-09 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Assembly of the not Module of the Human Ccr4-not Complex Nat.Struct.Mol.Biol., 20, 2013
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4C0F
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![BU of 4c0f by Molmil](/molmil-images/mine/4c0f) | Structure of the NOT-box domain of human CNOT2 | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2 | Authors: | Boland, A, Chen, Y, Raisch, T, Jonas, S, Izaurralde, E, Weichenrieder, O. | Deposit date: | 2013-08-01 | Release date: | 2013-10-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Assembly of the not Module of the Human Ccr4-not Complex Nat.Struct.Mol.Biol., 20, 2013
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4WBQ
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![BU of 4wbq by Molmil](/molmil-images/mine/4wbq) | Crystal structure of the exonuclease domain of QIP (QDE-2 interacting protein) solved by native-SAD phasing. | Descriptor: | CALCIUM ION, QDE-2-interacting protein | Authors: | Boland, A, Weinert, T, Weichenrieder, O, Wang, M. | Deposit date: | 2014-09-03 | Release date: | 2014-12-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.693 Å) | Cite: | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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4CRV
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![BU of 4crv by Molmil](/molmil-images/mine/4crv) | Complex of human CNOT9 and CNOT1 including two tryptophans | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, GLYCEROL, ... | Authors: | Boland, A, Chen, Y, Izaurralde, E, Weichenrieder, O. | Deposit date: | 2014-03-01 | Release date: | 2014-05-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing Mol.Cell, 54, 2014
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4C0E
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![BU of 4c0e by Molmil](/molmil-images/mine/4c0e) | Structure of the NOT1 superfamily homology domain from Chaetomium thermophilum | Descriptor: | NOT1 | Authors: | Chen, Y, Boland, A, Raisch, T, Jonas, S, Izaurralde, E, Weichenrieder, O. | Deposit date: | 2013-08-01 | Release date: | 2013-10-09 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and Assembly of the not Module of the Human Ccr4-not Complex Nat.Struct.Mol.Biol., 20, 2013
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4C0D
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![BU of 4c0d by Molmil](/molmil-images/mine/4c0d) | Structure of the NOT module of the human CCR4-NOT complex (CNOT1-CNOT2-CNOT3) | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 | Authors: | Raisch, T, Jonas, S, Boland, A, Chen, Y, Izaurralde, E, Weichenrieder, O. | Deposit date: | 2013-08-01 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and Assembly of the not Module of the Human Ccr4-not Complex Nat.Struct.Mol.Biol., 20, 2013
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9GAW
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![BU of 9gaw by Molmil](/molmil-images/mine/9gaw) | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2024-07-29 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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7QE7
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![BU of 7qe7 by Molmil](/molmil-images/mine/7qe7) | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2021-12-01 | Release date: | 2022-01-26 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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8QOT
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![BU of 8qot by Molmil](/molmil-images/mine/8qot) | Structure of the mu opioid receptor bound to the antagonist nanobody NbE | Descriptor: | Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... | Authors: | Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. | Deposit date: | 2023-09-29 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist. Biorxiv, 2023
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7OWG
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![BU of 7owg by Molmil](/molmil-images/mine/7owg) | human DEPTOR in a complex with mutant human mTORC1 A1459P | Descriptor: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | Authors: | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
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6TGB
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![BU of 6tgb by Molmil](/molmil-images/mine/6tgb) | CryoEM structure of the binary DOCK2-ELMO1 complex | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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6TGC
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![BU of 6tgc by Molmil](/molmil-images/mine/6tgc) | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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8PKP
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![BU of 8pkp by Molmil](/molmil-images/mine/8pkp) | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2023-06-27 | Release date: | 2023-07-19 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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7NJ1
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![BU of 7nj1 by Molmil](/molmil-images/mine/7nj1) | CryoEM structure of the human Separase-Securin complex | Descriptor: | Securin, Separin | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | Deposit date: | 2021-02-14 | Release date: | 2021-08-04 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596, 2021
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7NJ0
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![BU of 7nj0 by Molmil](/molmil-images/mine/7nj0) | CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ... | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | Deposit date: | 2021-02-14 | Release date: | 2021-08-04 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596, 2021
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6S53
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![BU of 6s53 by Molmil](/molmil-images/mine/6s53) | Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ... | Authors: | Kiss, L, Boland, A, Neuhaus, D, James, L.C. | Deposit date: | 2019-06-30 | Release date: | 2019-09-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nat Commun, 10, 2019
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6I27
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![BU of 6i27 by Molmil](/molmil-images/mine/6i27) | Rea1 AAA2L-H2alpha deletion mutant in AMPPNP State | Descriptor: | Midasin,Midasin,Midasin,Midasin,Midasin,Midasin,Midasin | Authors: | Sosnowski, P, Urnavicius, L, Boland, A, Fagiewicz, R, Busselez, J, Papai, G, Schmidt, H. | Deposit date: | 2018-10-31 | Release date: | 2018-12-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1. Elife, 7, 2018
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6HYD
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![BU of 6hyd by Molmil](/molmil-images/mine/6hyd) | Rea1 Wild type ADP state (tail part) | Descriptor: | Midasin,Midasin,Midasin | Authors: | Sosnowski, P, Urnavicius, L, Boland, A, Fagiewicz, R, Busselez, J, Papai, G, Schmidt, H. | Deposit date: | 2018-10-19 | Release date: | 2018-12-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1. Elife, 7, 2018
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6I26
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![BU of 6i26 by Molmil](/molmil-images/mine/6i26) | Rea1 Wild type AMPPNP state | Descriptor: | Midasin,Midasin,Midasin,Midasin | Authors: | Sosnowski, P, Urnavicius, L, Boland, A, Fagiewicz, R, Busselez, J, Papai, G, Schmidt, H. | Deposit date: | 2018-10-31 | Release date: | 2018-12-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1. Elife, 7, 2018
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6HYP
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![BU of 6hyp by Molmil](/molmil-images/mine/6hyp) | Rea1 Wild type ADP state (AAA+ ring part) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Midasin,Midasin | Authors: | Sosnowski, P, Urnavicius, L, Boland, A, Fagiewicz, R, Busselez, J, Papai, G, Schmidt, H. | Deposit date: | 2018-10-22 | Release date: | 2018-12-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1. Elife, 7, 2018
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8S4G
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![BU of 8s4g by Molmil](/molmil-images/mine/8s4g) | Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2024-02-21 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex To Be Published
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