7NRJ
 
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7O5T
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7O5N
 | | Crystal Structure of a Class D carbapenemase complexed with Avibactam | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1-BUTANOL, Beta-lactamase, ... | | 著者 | Zhou, Q, Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-04-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity
Acs Cent.Sci., 2023
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7O5Q
 | | Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin | | 分子名称: | (2R,4S)-2-[(1R)-2-butoxy-1-[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonylamino]-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidin-3-ium-4-carboxylic acid, (2R,4S)-2-[(R)-carboxy{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carbo xylic acid, 1-BUTANOL, ... | | 著者 | Zhou, Q, He, Y, Jin, Y. | | 登録日 | 2021-04-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin
To Be Published
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7O9N
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7PEI
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7PFN
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7PGO
 | | Crystal Structure of a Class D Carbapenemase_R250A | | 分子名称: | 1-BUTANOL, BROMIDE ION, Beta-lactamase | | 著者 | Zhou, Q, He, Y, Jin, Y. | | 登録日 | 2021-08-15 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity
Acs Cent.Sci., 2023
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7PEP
 | | Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Imipenem | | 分子名称: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, 1-BUTANOL, BROMIDE ION, ... | | 著者 | Zhou, Q, He, Y, Jin, Y. | | 登録日 | 2021-08-11 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity
Acs Cent.Sci., 2023
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7PEH
 | | Crystal Structure of a Class D Carbapenemase | | 分子名称: | 1-BUTANOL, Beta-lactamase | | 著者 | Zhou, Q, He, Y, Jin, Y. | | 登録日 | 2021-08-10 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity
Acs Cent.Sci., 2023
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7PSE
 | | Crystal Structure of a Class D Carbapenemase_K73ALY Complexed with Oxacillin | | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, 1-BUTANOL, Beta-lactamase, ... | | 著者 | Zhou, Q, He, Y, Jin, Y. | | 登録日 | 2021-09-23 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity
Acs Cent.Sci., 2023
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7PSF
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7Q14
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8CMK
 | | Transportin-3 TNPO3 in complex with RSY region of CIRBP | | 分子名称: | 2-(1H-INDOL-3-YL)ETHANAMINE, Cold-inducible RNA-binding protein, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Zhou, Q, Sagmeister, T, Pavkov-Keller, T, Madl, T. | | 登録日 | 2023-02-20 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.945 Å) | | 主引用文献 | Tyrosine mediated nuclear import of CIRBP reveals a flexible NLS recognition by TNPO3
To Be Published
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5W5D
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5W5C
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5CCI
 | | Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | 分子名称: | MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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5CCH
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | 分子名称: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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5CCJ
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5CCG
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) | | 分子名称: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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4HND
 | | Crystal structure of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha | | 著者 | Zhou, Q, Zhai, Y, Zhang, K, Chen, C, Sun, F. | | 登録日 | 2012-10-19 | | 公開日 | 2014-04-09 | | 最終更新日 | 2016-12-28 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
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4HNE
 | | Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha | | 著者 | Zhou, Q, Zhai, Y, Zhang, K, Chen, C, Sun, F. | | 登録日 | 2012-10-19 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
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8ILV
 | | Cryo-EM structure of PI3Kalpha in complex with compound 18 | | 分子名称: | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8ILR
 | | Cryo-EM structure of PI3Kalpha in complex with compound 16 | | 分子名称: | N-[(2S)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8ILS
 | | Cryo-EM structure of PI3Kalpha in complex with compound 17 | | 分子名称: | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
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