5W9N
 
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5KF4
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8WKJ
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8WOU
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8X5D
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1SO8
 | | Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)] | | Descriptor: | 3-hydroxyacyl-CoA dehydrogenase type II, CHLORIDE ION, SODIUM ION | | Authors: | Lustbader, J.W, Cirilli, M, Wu, H. | | Deposit date: | 2004-03-13 | | Release date: | 2004-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science, 304, 2004
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7KBB
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7KBA
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7YLO
 | | Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria Metabolic network of tryptophan around the indole-3-aldehyde formation | | Descriptor: | Dyp-type peroxidase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Cheng, J, Luo, Y, Zhu, J, Tan, R, Wang, N, Lebedev, A.A. | | Deposit date: | 2022-07-26 | | Release date: | 2023-07-05 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria
Metabolic network of tryptophan around the indole-3-aldehyde formation
To Be Published
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7YMJ
 | | Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | | Descriptor: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | | Deposit date: | 2022-07-28 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
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7YMH
 | | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | | Descriptor: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | | Deposit date: | 2022-07-28 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
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7YM8
 | | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | | Deposit date: | 2022-07-27 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
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7YUF
 | | apo human SPNS2 | | Descriptor: | NbFab H-chain, NbFab L-chain, Sphingosine-1-phosphate transporter SPNS2, ... | | Authors: | He, Y, Duan, Y. | | Deposit date: | 2022-08-17 | | Release date: | 2023-09-06 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
Cell Res., 34, 2024
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7YUD
 | | FTY720p-bound human SPNS2 | | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, NbFab L-chain, NbFab-H-chain, ... | | Authors: | He, Y, Duan, Y. | | Deposit date: | 2022-08-17 | | Release date: | 2023-09-06 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
Cell Res., 34, 2024
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2W08
 | | The structure of serum amyloid P component bound to 0-phospho- threonine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PHOSPHOTHREONINE, ... | | Authors: | Kolstoe, S.E, Pepys, M.B, Wood, S.P. | | Deposit date: | 2008-08-12 | | Release date: | 2009-04-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Molecular Dissection of Alzheimer'S Disease Neuropathology by Depletion of Serum Amyloid P Component.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4M5C
 | | Crystal Structure of an Truncated Transition metal Transporter | | Descriptor: | COBALT (II) ION, Cobalamin biosynthesis protein CbiM, HEXANE-1,6-DIOL | | Authors: | Yu, Y, Zhou, M.Z, Gu, J.K. | | Deposit date: | 2013-08-08 | | Release date: | 2014-03-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
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6A53
 | | Crystal structure of DddK | | Descriptor: | MANGANESE (II) ION, Novel protein with potential Cupin domain | | Authors: | Zhang, Y.Z, Li, C.Y. | | Deposit date: | 2018-06-21 | | Release date: | 2019-02-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.
Appl. Environ. Microbiol., 85, 2019
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6A54
 | | Crystal structure of DddK mutant Y64A | | Descriptor: | MANGANESE (II) ION, Novel protein with potential Cupin domain | | Authors: | Zhang, Y.Z, Li, C.Y. | | Deposit date: | 2018-06-21 | | Release date: | 2019-02-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.
Appl. Environ. Microbiol., 85, 2019
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6A55
 | | Crystal structure of DddK mutant Y122A | | Descriptor: | 3-(dimethyl-lambda~4~-sulfanyl)propanoic acid, MANGANESE (II) ION, Novel protein with potential Cupin domain | | Authors: | Zhang, Y.Z, Li, C.Y. | | Deposit date: | 2018-06-21 | | Release date: | 2019-02-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.
Appl. Environ. Microbiol., 85, 2019
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8WW2
 | | GPR3/Gs complex | | Descriptor: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | He, Y, Xiong, Y. | | Deposit date: | 2023-10-24 | | Release date: | 2024-02-14 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Identification of oleic acid as an endogenous ligand of GPR3.
Cell Res., 34, 2024
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8FOW
 | | Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib | | Descriptor: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... | | Authors: | Schonbrunn, E, Sun, L. | | Deposit date: | 2023-01-03 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun, 14, 2023
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8FP5
 | | CDK2 liganded with ATP and Mg2+ | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclin-dependent kinase 2, ... | | Authors: | Schonbrunn, E, Sun, L. | | Deposit date: | 2023-01-04 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun, 14, 2023
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8FP0
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7WE8
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | | Authors: | Wang, X, Wang, L. | | Deposit date: | 2021-12-23 | | Release date: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WEC
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