2WC0
| crystal structure of human insulin degrading enzyme in complex with iodinated insulin | 分子名称: | 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | 登録日 | 2009-03-06 | 公開日 | 2009-03-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
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2WBY
| Crystal structure of human insulin-degrading enzyme in complex with insulin | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ... | 著者 | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | 登録日 | 2009-03-06 | 公開日 | 2009-03-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
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2WK3
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7RZI
| Insulin Degrading Enzyme pC/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZG
| Insulin Degrading Enzyme O/pO | 分子名称: | Cysteine-free Insulin-degrading enzyme | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZH
| Insulin Degrading Enzyme O/O | 分子名称: | Cysteine-free Insulin-degrading enzyme | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZF
| Insulin Degrading Enzyme O/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZE
| Insulin Degrading Enzyme pO/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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1YRU
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1YRT
| Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin | 分子名称: | Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin | 著者 | Guo, Q, Shen, Y, Lee, Y.S, Gibbs, C.S, Mrksich, M, Tang, W.J. | 登録日 | 2005-02-04 | 公開日 | 2006-01-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. Embo J., 24, 2005
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1ZOT
| crystal structure analysis of the CyaA/C-Cam with PMEAPP | 分子名称: | (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... | 著者 | Guo, Q, Tang, W.J. | 登録日 | 2005-05-13 | 公開日 | 2005-08-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. Embo J., 24, 2005
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2COL
| Crystal structure analysis of CyaA/C-Cam with Pyrophosphate | 分子名称: | Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin, ... | 著者 | Guo, Q, Tang, W.J, Shen, Y. | 登録日 | 2005-05-18 | 公開日 | 2006-01-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin Embo J., 24, 2005
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3H44
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3HGZ
| Crystal structure of human insulin-degrading enzyme in complex with amylin | 分子名称: | Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION | 著者 | Guo, Q, Bian, Y, Tang, W.J. | 登録日 | 2009-05-14 | 公開日 | 2009-12-08 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
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3CQF
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3CWW
| Crystal Structure of IDE-bradykinin complex | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ... | 著者 | Malito, E, Tang, W.J. | 登録日 | 2008-04-23 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme Biochemistry, 47, 2008
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3E4A
| Human IDE-inhibitor complex at 2.6 angstrom resolution | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ... | 著者 | Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J. | 登録日 | 2008-08-11 | 公開日 | 2009-05-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One, 5, 2010
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1PK0
| Crystal Structure of the EF3-CaM complexed with PMEApp | 分子名称: | (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... | 著者 | Shen, Y, Tang, W.J. | 登録日 | 2003-06-04 | 公開日 | 2004-02-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc.Natl.Acad.Sci.USA, 101, 2004
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1XFX
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride | 分子名称: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2017-12-20 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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1XFZ
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride | 分子名称: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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1XFU
| Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin | 分子名称: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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1XFY
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin | 分子名称: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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1XFW
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP) | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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1XFV
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ... | 著者 | Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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3TN2
| structure analysis of MIP1-beta P8A | 分子名称: | C-C motif chemokine 4, ZINC ION | 著者 | Guo, Q, Tang, W.J. | 登録日 | 2011-09-01 | 公開日 | 2012-09-05 | 最終更新日 | 2018-08-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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