5BNG
| monomer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA | 分子名称: | DNA (5'-D(P*AP*AP*TP*TP*AP*GP*CP*TP*GP*TP*CP*A)-3'), DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A)-3'), DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A-3'), ... | 著者 | Morgunova, E, Jolma, A, Yin, Y, Nitta, K, Dave, K, Popov, A, Taipale, M, Enge, M, Kivioja, T, Taipale, J. | 登録日 | 2015-05-26 | 公開日 | 2015-11-04 | 最終更新日 | 2015-12-02 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
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5HOD
| Structure of LHX4 transcription factor complexed with DNA | 分子名称: | DNA (5'-D(P*AP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*GP*TP*AP*AP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*TP*TP*AP*CP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*T)-3'), LIM/homeobox protein Lhx4 | 著者 | Morgunova, E, Yin, Y, Popov, A, Taipale, J. | 登録日 | 2016-01-19 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.682 Å) | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
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8OSB
| TWIST1-TCF4-ALX4 complex on specific DNA | 分子名称: | DNA (25-MER), Homeobox protein aristaless-like 4, Transcription factor 4, ... | 著者 | Morgunova, E, Kim, S, Popov, A, Wysocka, J, Taipale, J. | 登録日 | 2023-04-18 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | DNA-guided transcription factor cooperativity shapes face and limb mesenchyme. Cell, 187, 2024
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5LTY
| Homeobox transcription factor CDX2 bound to methylated DNA | 分子名称: | DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2 | 著者 | Morgunova, E, Popov, A, Taipale, J. | 登録日 | 2016-09-07 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
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5LUX
| Homeobox transcription factor CDX1 bound to methylated DNA | 分子名称: | DNA (5'-D(P*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*C)-3'), ... | 著者 | Morgunova, E, Popov, A, Taipale, J. | 登録日 | 2016-09-12 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
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4XRM
| homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(P*AP*GP*CP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*GP*C)-3'), ... | 著者 | Morgunova, E, Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Taipale, J. | 登録日 | 2015-01-21 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
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4XRS
| Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA | 分子名称: | DNA (5'-D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3'), ... | 著者 | Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Morgunova, E, Taipale, J. | 登録日 | 2015-01-21 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
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8BYX
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8BZM
| FOXK1-ELF1-heterodimer bound to DNA | 分子名称: | DNA, ETS-related transcription factor Elf-1, Forkhead box protein K1, ... | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | 登録日 | 2022-12-15 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | FOXK1-ELF1_heterodimer bound to DNA To Be Published
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7PSX
| Structure of HOXB13 bound to hydroxymethylated DNA | 分子名称: | DNA (5'-D(P*GP*GP*AP*CP*CP*TP*5HCP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13, ... | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | 登録日 | 2021-09-24 | 公開日 | 2022-10-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of HOXB13 bound to hydroxymethylated DNA To Be Published
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5EGO
| HOXB13-MEIS1 heterodimer bound to methylated DNA | 分子名称: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | 登録日 | 2015-10-27 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
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5EF6
| Structure of HOXB13 complex with methylated DNA | 分子名称: | DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13 | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | 登録日 | 2015-10-23 | 公開日 | 2017-02-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
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7Z5I
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7Z5K
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7Q3O
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7Q4N
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6ES2
| Structure of CDX2-DNA(CAA) | 分子名称: | DNA (5'-D(P*GP*GP*AP*GP*GP*CP*AP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*TP*TP*GP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2 | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | 登録日 | 2017-10-19 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima. Elife, 7, 2018
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6ES3
| Structure of CDX2-DNA(TCG) | 分子名称: | DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2 | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | 登録日 | 2017-10-19 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima. Elife, 7, 2018
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6SJD
| ZC3H12B-ribonuclease domain bound to RNA | 分子名称: | CACODYLATE ION, MAGNESIUM ION, Probable ribonuclease ZC3H12B, ... | 著者 | Morgunova, E, Bourenkov, G, Taipale, J. | 登録日 | 2019-08-13 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences. Genome Res., 30, 2020
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4YO2
| Structure of E2F8, an atypical member of E2F family of transcription factors | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*CP*CP*CP*GP*CP*CP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*GP*GP*CP*GP*GP*GP*AP*AP*AP*A)-3'), Transcription factor E2F8 | 著者 | Morgunova, E, Yin, Y, Jolma, A, Dave, K, Schmierer, B, Popov, A, Eremina, N, Nilsson, L, Taipale, J. | 登録日 | 2015-03-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.073 Å) | 主引用文献 | Structural insights into the DNA-binding specificity of E2F family transcription factors. Nat Commun, 6, 2015
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5NNX
| TEAD1 bound to DNA | 分子名称: | DNA, Transcriptional enhancer factor TEF-1 | 著者 | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | 登録日 | 2017-04-10 | 公開日 | 2017-04-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | TEAD1 bound to DNA To Be Published
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5NO6
| TEAD4-HOXB13 complex bound to DNA | 分子名称: | DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 | 著者 | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | 登録日 | 2017-04-11 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | TEAD4-HOXB13 complex bound to DNA To Be Published
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6T78
| Structure of human Sox11 transcription factor in complex with a short DNA fragment | 分子名称: | DNA (5'-D(*AP*AP*CP*AP*AP*AP*AP*TP*AP*AP*AP*CP*AP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*TP*GP*TP*TP*TP*AP*TP*TP*TP*TP*GP*TP*T)-3'), Transcription factor SOX-11 | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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6T79
| Structure of a human nucleosome at 3.2 A resolution | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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6T7C
| Structure of two copies of human Sox11 transcription factor in complex with a nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2020-05-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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