5EF6
Structure of HOXB13 complex with methylated DNA
Summary for 5EF6
Entry DOI | 10.2210/pdb5ef6/pdb |
Descriptor | Homeobox protein Hox-B13, DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), ... (4 entities in total) |
Functional Keywords | transcription factor, methylated dna, complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: Q92826 |
Total number of polymer chains | 12 |
Total formula weight | 74280.46 |
Authors | Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-23, release date: 2017-02-08, Last modification date: 2024-01-10) |
Primary citation | Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356:-, 2017 Cited by PubMed: 28473536DOI: 10.1126/science.aaj2239 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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