5LTY

Homeobox transcription factor CDX2 bound to methylated DNA

Summary for 5LTY

• Entry DOI: 10.2210/pdb5lty/pdb
• Descriptor: DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2, DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), ... (4 entities in total)
• Functional Keywords: transcription, transcription factor, methylated dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q99626
• Total number of polymer chains: 6
• Total formula weight: 39856.92

Authors

Morgunova, E.,Popov, A.,Taipale, J. (deposition date: 2016-09-07, release date: 2017-05-31, Last modification date: 2024-01-17)

• Primary citation: Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J.; Impact of cytosine methylation on DNA binding specificities of human transcription factors.; Science, 356:-, 2017; PubMed: 28473536; DOI: 10.1126/science.aaj2239

Experimental method

X-RAY DIFFRACTION (2.66 Å)