4JL9
 
 | | Crystal structure of mouse TBK1 bound to BX795 | | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | | 著者 | Li, P, Shu, C. | | 登録日 | 2013-03-12 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.0999 Å) | | 主引用文献 | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
Structure, 21, 2013
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5JEJ
 | | Phosphorylated STING in complex with IRF-3 CTD | | 分子名称: | Interferon regulatory factor 3, Stimulator of interferon genes protein | | 著者 | Li, P, Shu, C. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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1N1A
 | | Crystal Structure of the N-terminal domain of human FKBP52 | | 分子名称: | FKBP52 | | 著者 | Li, P, Ding, Y, Wu, B, Shu, C, Shen, B, Rao, Z. | | 登録日 | 2002-10-16 | | 公開日 | 2002-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of the N-terminal domain of human FKBP52.
Acta Crystallogr.,Sect.D, 59, 2003
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1P5Q
 | | Crystal Structure of FKBP52 C-terminal Domain | | 分子名称: | FK506-binding protein 4, SULFATE ION | | 著者 | Wu, B, Li, P, Lou, Z, Shu, C, Ding, Y, Shen, B, Rao, Z. | | 登録日 | 2003-04-28 | | 公開日 | 2004-06-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Proc.Natl.Acad.Sci.USA, 101, 2004
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1Q1C
 | | Crystal structure of N(1-260) of human FKBP52 | | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, FK506-binding protein 4 | | 著者 | Wu, B, Li, P, Lou, Z, Ding, Y, Shu, C, Shen, B, Rao, Z. | | 登録日 | 2003-07-18 | | 公開日 | 2004-06-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Proc.Natl.Acad.Sci.USA, 101, 2004
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1QZ2
 | | Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90 | | 分子名称: | 5-mer peptide from Heat shock protein HSP 90, FK506-binding protein 4 | | 著者 | Wu, B, Li, P, Lou, Z, Liu, Y, Ding, Y, Shu, C, Shen, B, Rao, Z. | | 登録日 | 2003-09-15 | | 公開日 | 2004-06-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1J4I
 | | crystal structure analysis of the FKBP12 complexed with 000308 small molecule | | 分子名称: | 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID, FKBP12 | | 著者 | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | | 登録日 | 2001-09-30 | | 公開日 | 2003-06-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
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1J4H
 | | crystal structure analysis of the FKBP12 complexed with 000107 small molecule | | 分子名称: | 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER, FKBP12 | | 著者 | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | | 登録日 | 2001-09-30 | | 公開日 | 2003-06-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
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3U9M
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3U9J
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4EMT
 | | Crystal Structure of human STING bound to c-di-GMP | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | | 著者 | Li, P. | | 登録日 | 2012-04-12 | | 公開日 | 2012-06-13 | | 最終更新日 | 2012-07-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
Nat.Struct.Mol.Biol., 19, 2012
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4EMU
 | | Crystal structure of ligand free human STING | | 分子名称: | CALCIUM ION, Transmembrane protein 173 | | 著者 | Li, P. | | 登録日 | 2012-04-12 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
Nat.Struct.Mol.Biol., 19, 2012
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4JLC
 | | Crystal structure of mouse TBK1 bound to SU6668 | | 分子名称: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | | 著者 | Li, P. | | 登録日 | 2013-03-12 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
Structure, 21, 2013
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8FBI
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8FBJ
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8FBN
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8FBO
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8FBK
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6O8C
 | | Crystal structure of STING CTT in complex with TBK1 | | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | 著者 | Li, P, Zhao, B, Du, F. | | 登録日 | 2019-03-09 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | | 主引用文献 | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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6O8B
 | | Crystal structure of STING CTD in complex with TBK1 | | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | 著者 | Li, P, Zhao, B, Du, F. | | 登録日 | 2019-03-09 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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5V5F
 | | Crystal structure of RICE1 (PNT2) | | 分子名称: | At3g11770 | | 著者 | Li, P. | | 登録日 | 2017-03-14 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.945 Å) | | 主引用文献 | RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana.
Elife, 6, 2017
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2FKY
 | | crystal structure of KSP in complex with inhibitor 13 | | 分子名称: | (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Yan, Y. | | 登録日 | 2006-01-05 | | 公開日 | 2006-02-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16, 2006
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2FL2
 | | crystal structure of KSP in complex with inhibitor 19 | | 分子名称: | (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Yan, Y. | | 登録日 | 2006-01-05 | | 公開日 | 2006-02-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16, 2006
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2FL6
 | | crystal structure of KSP in complex with inhibitor 6 | | 分子名称: | (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | 著者 | Yan, Y. | | 登録日 | 2006-01-05 | | 公開日 | 2006-02-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16, 2006
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5JEK
 | | Phosphorylated MAVS in complex with IRF-3 | | 分子名称: | Interferon regulatory factor 3, MAVS peptide | | 著者 | Zhao, B, Li, P. | | 登録日 | 2016-04-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2016-06-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
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