4EMT

Crystal Structure of human STING bound to c-di-GMP

Summary for 4EMT

• Entry DOI: 10.2210/pdb4emt/pdb
• Related: 4EMU
• Descriptor: Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, ... (4 entities in total)
• Functional Keywords: alpha/beta fold, innate immune sensor, c-di-gmp, c-di-amp, membrane protein
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 43966.38

Authors

Li, P. (deposition date: 2012-04-12, release date: 2012-06-13, Last modification date: 2012-07-25)

• Primary citation: Shu, C.,Yi, G.,Watts, T.,Kao, C.C.,Li, P.; Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.; Nat.Struct.Mol.Biol., 19:722-724, 2012; PubMed: 22728658; DOI: 10.1038/nsmb.2331

Experimental method

X-RAY DIFFRACTION (1.5 Å)