4EMT

Crystal Structure of human STING bound to c-di-GMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002218	biological_process	activation of innate immune response
A	0032481	biological_process	positive regulation of type I interferon production
B	0002218	biological_process	activation of innate immune response
B	0032481	biological_process	positive regulation of type I interferon production

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	BINDING SITE FOR RESIDUE C2E A 401

Chain	Residue
A	SER162
A	HOH502
A	HOH503
A	HOH507
A	HOH512
A	HOH531
A	HOH535
A	HOH536
A	HOH538
A	HOH540
A	HOH555
A	TYR163
A	HOH558
A	HOH565
A	HOH572
A	HOH574
A	HOH597
A	HOH600
B	SER162
B	GLY166
B	TYR167
B	TYR240
A	GLY166
B	GLU260
B	THR263
B	PRO264
B	HOH503
B	HOH531
B	HOH547
A	TYR167
A	ARG238
A	TYR240
A	GLU260
A	THR263
A	PRO264

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 401

Chain	Residue
B	ASP205
B	GLU316
B	ALA318
B	ASP320
B	HOH502
B	HOH558

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37379839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GJX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31968013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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