4EMT
Crystal Structure of human STING bound to c-di-GMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE C2E A 401 |
| Chain | Residue |
| A | SER162 |
| A | HOH502 |
| A | HOH503 |
| A | HOH507 |
| A | HOH512 |
| A | HOH531 |
| A | HOH535 |
| A | HOH536 |
| A | HOH538 |
| A | HOH540 |
| A | HOH555 |
| A | TYR163 |
| A | HOH558 |
| A | HOH565 |
| A | HOH572 |
| A | HOH574 |
| A | HOH597 |
| A | HOH600 |
| B | SER162 |
| B | GLY166 |
| B | TYR167 |
| B | TYR240 |
| A | GLY166 |
| B | GLU260 |
| B | THR263 |
| B | PRO264 |
| B | HOH503 |
| B | HOH531 |
| B | HOH547 |
| A | TYR167 |
| A | ARG238 |
| A | TYR240 |
| A | GLU260 |
| A | THR263 |
| A | PRO264 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 401 |
| Chain | Residue |
| B | ASP205 |
| B | GLU316 |
| B | ALA318 |
| B | ASP320 |
| B | HOH502 |
| B | HOH558 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
| Chain | Residue | Details |
| B | SER162 | |
| A | SER162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | TYR167 | |
| B | TYR167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
| Chain | Residue | Details |
| A | ARG238 | |
| B | ARG238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | THR263 | |
| B | THR263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | THR229 | |
| B | THR229 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | SER241 | |
| B | SER241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | LYS338 | |
| B | LYS338 |
