4EMT
Crystal Structure of human STING bound to c-di-GMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transmembrane protein 173 | polymer | 188 | 21617.9 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING |
| 2 | C (A) | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) | non-polymer | 690.4 | 1 | Chemie (C2E) | |||
| 3 | D (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 154 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43235.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 730.5 | |
| All* | Total formula weight | 43966.4 |
