4EMU

Crystal structure of ligand free human STING

Summary for 4EMU

• Entry DOI: 10.2210/pdb4emu/pdb
• Related: 4EMT
• Descriptor: Transmembrane protein 173, CALCIUM ION (3 entities in total)
• Functional Keywords: alpha/beta fold, innate immune sensor, c-di-gmp, membrane protein
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Multi-pass membrane protein : Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 43088.39

Authors

Li, P. (deposition date: 2012-04-12, release date: 2012-06-13, Last modification date: 2024-02-28)

• Primary citation: Shu, C.,Yi, G.,Watts, T.,Kao, C.C.,Li, P.; Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.; Nat.Struct.Mol.Biol., 19:722-724, 2012; PubMed: 22728658; DOI: 10.1038/nsmb.2331

Experimental method

X-RAY DIFFRACTION (1.9 Å)