2FKY

crystal structure of KSP in complex with inhibitor 13

Summary for 2FKY

• Entry DOI: 10.2210/pdb2fky/pdb
• Related: 2FL2 2FL6
• Descriptor: Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: ksp, ksp-inhibitor complex, cell cycle
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P52732
• Total number of polymer chains: 2
• Total formula weight: 83546.71

Authors

Yan, Y. (deposition date: 2006-01-05, release date: 2006-02-07, Last modification date: 2024-02-14)

• Primary citation: Fraley, M.E.,Garbaccio, R.M.,Arrington, K.L.,Hoffman, W.F.,Tasber, E.S.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Fernandes, C.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Shu, C.,Torrent, M.,Heimbrook, D.C.,Kohl, N.E.,Huber, H.E.,Hartman, G.D.; Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.; Bioorg.Med.Chem.Lett., 16:1775-1779, 2006; PubMed: 16439123; DOI: 10.1016/j.bmcl.2006.01.030

Experimental method

X-RAY DIFFRACTION (2.3 Å)