8SQZ
 
 | |
8SRQ
 | | Structure of human ULK1C:PI3KC3-C1 supercomplex | | Descriptor: | Autophagy-related protein 13, Beclin 1-associated autophagy-related key regulator, Beclin-1-C 35 kDa, ... | | Authors: | Chen, M, Hurley, J.H. | | Deposit date: | 2023-05-05 | | Release date: | 2023-06-21 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
bioRxiv, 2023
|
|
8SOI
 | | Structure of human ULK1 complex core (2:1:1 stoichiometry) | | Descriptor: | Autophagy-related protein 13, RB1-inducible coiled-coil protein 1, Serine/threonine-protein kinase ULK1 | | Authors: | Chen, M, Hurley, J.H. | | Deposit date: | 2023-04-28 | | Release date: | 2023-06-21 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
bioRxiv, 2023
|
|
8SRM
 | |
6CYT
 | | HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb | | Descriptor: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | | Authors: | Schulze Gahmen, U, Hurley, J.H. | | Deposit date: | 2018-04-06 | | Release date: | 2018-12-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5JW9
 | |
6OWT
 | | Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex | | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ... | | Authors: | Buffalo, C.Z, Ren, X, Hurley, J.H. | | Deposit date: | 2019-05-10 | | Release date: | 2019-09-25 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
Cell Host Microbe, 26, 2019
|
|
6PAS
 | | Inactive State of Manduca sexta soluble guanylate cyclase | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | | Deposit date: | 2019-06-11 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.
Elife, 8, 2019
|
|
6PAT
 | | Active State of Manduca sexta soluble Guanylate Cyclase | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | | Deposit date: | 2019-06-11 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.
Elife, 8, 2019
|
|
7UX3
 | | Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Hooy, R.M, Hurley, J.H. | | Deposit date: | 2022-05-04 | | Release date: | 2023-05-10 | | Last modified: | 2023-06-14 | | Method: | ELECTRON MICROSCOPY (9.6 Å) | | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
|
|
7MU2
 | | Crystal Structure of WIPI2 in complex with W2IR of ATG16L1 | | Descriptor: | Autophagy-related protein 16-1, WD repeat domain phosphoinositide-interacting protein 2 | | Authors: | Strong, L.M, Flower, T.G, Buffalo, C.Z, Hurley, J.H. | | Deposit date: | 2021-05-14 | | Release date: | 2021-05-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.
Elife, 10, 2021
|
|
7MGE
 | | Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | | Descriptor: | ADP-ribosylation factor 1, BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Su, M.-Y, Hurley, J.H. | | Deposit date: | 2021-04-12 | | Release date: | 2021-06-23 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Structural basis for the ARF GAP activity and specificity of the C9orf72 complex.
Nat Commun, 12, 2021
|
|
6CM9
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | | Deposit date: | 2018-03-03 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
|
|
6CRI
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Hurley, J.H. | | Deposit date: | 2018-03-18 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
|
|
6DCE
 | | X-ray structure of FIP200 claw domain | | Descriptor: | RB1-inducible coiled-coil protein 1, SULFATE ION | | Authors: | Su, M.-Y, Hurley, J.H. | | Deposit date: | 2018-05-05 | | Release date: | 2019-03-06 | | Last modified: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates.
Mol. Cell, 74, 2019
|
|
6D84
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | | Deposit date: | 2018-04-25 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.72 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
|
|
6DFF
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H. | | Deposit date: | 2018-05-14 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
|
|
2ZME
 | |
6D83
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | | Deposit date: | 2018-04-25 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.27 Å) | | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
|
|
3CUQ
 | |
5HM9
 | | Crystal structure of MamO protease domain from Magnetospirillum magneticum (apo form) | | Descriptor: | MamO protease domain, poly(UNK) | | Authors: | Hershey, D.M, Ren, X, Hurley, J.H, Komeili, A. | | Deposit date: | 2016-01-15 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria.
Plos Biol., 14, 2016
|
|
5HMA
 | | Crystal structure of MamO protease domain from Magnetospirillum magneticum (Ni bound form) | | Descriptor: | CHLORIDE ION, NICKEL (II) ION, Trypsin-like serine protease, ... | | Authors: | Hershey, D.M, Ren, X, Hurley, J.H, Komeili, A. | | Deposit date: | 2016-01-15 | | Release date: | 2016-02-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.299 Å) | | Cite: | MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria.
Plos Biol., 14, 2016
|
|
6VME
 | | Human ESCRT-I heterotetramer headpiece | | Descriptor: | Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... | | Authors: | Flower, T.G, Hurley, J.H, Tjahjono, N. | | Deposit date: | 2020-01-27 | | Release date: | 2020-05-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
Nat.Struct.Mol.Biol., 27, 2020
|
|
6WCW
 | | Structure of human Rubicon RH domain in complex with GTP-bound Rab7 | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... | | Authors: | Bhargava, H.K, Byck, J.M, Farrell, D.P, Anishchenko, I, DiMaio, F, Im, Y.J, Hurley, J.H. | | Deposit date: | 2020-03-31 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WJ3
 | |
