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3AYU
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BU of 3ayu by Molmil
Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor
Descriptor: 72 kDa type IV collagenase, Amyloid beta A4 protein, CALCIUM ION, ...
Authors:Hashimoto, H, Takeuchi, T, Komatsu, K, Miyazaki, K, Sato, M, Higashi, S.
Deposit date:2011-05-17
Release date:2011-08-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor
J.Biol.Chem., 2011
2ZO1
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BU of 2zo1 by Molmil
Mouse NP95 SRA domain DNA specific complex 2
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), ...
Authors:Hashimoto, H, Horton, J.R, Cheng, X.
Deposit date:2008-05-05
Release date:2008-09-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
2ZO0
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BU of 2zo0 by Molmil
mouse NP95 SRA domain DNA specific complex 1
Descriptor: DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), E3 ubiquitin-protein ligase UHRF1
Authors:Hashimoto, H, Horton, J.R, Cheng, X.
Deposit date:2008-05-05
Release date:2008-09-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
3ALR
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BU of 3alr by Molmil
Crystal structure of Nanos
Descriptor: Nanos protein, ZINC ION
Authors:Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M.
Deposit date:2010-08-06
Release date:2011-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of zinc-finger domain of Nanos and its functional implications
Embo Rep., 11, 2010
2ZO2
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BU of 2zo2 by Molmil
Mouse NP95 SRA domain non-specific DNA complex
Descriptor: DNA (5'-D(*DAP*DAP*DCP*DTP*DGP*DCP*DGP*DCP*DAP*DGP*DTP*DT)-3'), E3 ubiquitin-protein ligase UHRF1, PHOSPHATE ION
Authors:Hashimoto, H, Horton, J.R, Cheng, X.
Deposit date:2008-05-05
Release date:2008-09-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
5YD8
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BU of 5yd8 by Molmil
Crystal structure of human PCNA in complex with APIM of human ZRANB3
Descriptor: Proliferating cell nuclear antigen, ZRANB3
Authors:Hashimoto, H, Tagata, R.
Deposit date:2017-09-12
Release date:2018-04-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
Acta Crystallogr.,Sect.F, 74, 2018
3W08
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BU of 3w08 by Molmil
Crystal structure of aldoxime dehydratase
Descriptor: Aldoxime dehydratase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hashimoto, H, Nomura, J, Hashimoto, Y, Oinuma, K.I, Wada, K, Hishiki, A, Hara, K, Kobayashi, M.
Deposit date:2012-10-24
Release date:2013-02-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
3A57
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BU of 3a57 by Molmil
Crystal structure of Thermostable Direct Hemolysin
Descriptor: Thermostable direct hemolysin 2
Authors:Hashimoto, H, Yanagihara, I, Nakahira, K, Hamada, D, Ikegami, T, Mayanagi, K, Kaieda, S, Fukui, T, Ohnishi, K, Kajiyama, S, Yamane, T, Ikeguchi, M, Honda, T, Shimizu, T, Sato, M.
Deposit date:2009-08-03
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin
J.Biol.Chem., 285, 2010
3WGW
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BU of 3wgw by Molmil
Structure of PCNA bound to a small molecule inhibitor
Descriptor: 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION
Authors:Hashimoto, H.
Deposit date:2013-08-12
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
J.Biol.Chem., 289, 2014
3VKX
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BU of 3vkx by Molmil
Structure of PCNA
Descriptor: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ...
Authors:Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N.
Deposit date:2011-11-26
Release date:2012-03-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
7BR0
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BU of 7br0 by Molmil
Crystal structure of AclR, a thioredoxin oxidoreductase fold protein carrying the CXXH catalytic motif
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Pyr_redox_2 domain-containing protein
Authors:Hara, K, Hashimoto, H, Maeda, N, Watanabe, K, Hertweck, C, Tsunematsu, Y.
Deposit date:2020-03-26
Release date:2020-12-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis.
J.Am.Chem.Soc., 143, 2021
8W7D
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BU of 8w7d by Molmil
Crystal structure of EcPPAT-FR901483 complex
Descriptor: Amidophosphoribosyltransferase, [(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate
Authors:Hara, K, Hashimoto, H, Nakahara, M, Sato, M, Watanabe, K.
Deposit date:2023-08-30
Release date:2023-12-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor.
J.Am.Chem.Soc., 145, 2023
8WU8
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BU of 8wu8 by Molmil
Crystal structure of the human RAD9-RAD1(F64A/M256A/F266A)-HUS1-RHINO(88-99) complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ...
Authors:Hara, K, Nagata, K, Iida, N, Hashimoto, H.
Deposit date:2023-10-20
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO.
J.Biol.Chem., 300, 2024
8FJN
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BU of 8fjn by Molmil
Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - C2221 space group
Descriptor: CALCIUM ION, CHLORIDE ION, Histone-lysine N-methyltransferase, ...
Authors:Frisbie, V.S, Hashimoto, H, Debler, E.W.
Deposit date:2022-12-20
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase
To Be Published
8FJM
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BU of 8fjm by Molmil
Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - P212121 space group
Descriptor: ACETATE ION, CALCIUM ION, Histone-lysine N-methyltransferase, ...
Authors:Frisbie, V.S, Hashimoto, H, Debler, E.W.
Deposit date:2022-12-20
Release date:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase
To Be Published
8Y2S
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BU of 8y2s by Molmil
P-hydroxybenzoate hydroxylase complexed with 4-hydroxy-3-methylbenzoic acid
Descriptor: 3-methyl-4-oxidanyl-benzoic acid, 4-hydroxybenzoate 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K.
Deposit date:2024-01-27
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional Enhancement of Flavin-Containing Monooxygenase through Machine Learning Methodology
Acs Catalysis, 14, 2024
5FHI
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BU of 5fhi by Molmil
Crystallographic structure of PsoE without Co
Descriptor: GLUTATHIONE, Glutathione S-transferase, putative
Authors:Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
5F8B
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BU of 5f8b by Molmil
Crystallographic Structure of PsoE with Co
Descriptor: (5~{S},8~{S},9~{R})-2-[(~{E})-hex-1-enyl]-8-methoxy-3-methyl-9-oxidanyl-8-(phenylcarbonyl)-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, COBALT (II) ION, GLUTATHIONE, ...
Authors:Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K.
Deposit date:2015-12-09
Release date:2016-04-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
1WN7
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BU of 1wn7 by Molmil
Crystal structure of archaeal family B DNA polymerase mutant
Descriptor: Family B DNA Polymerase, GLYCEROL, NICKEL (II) ION
Authors:Kuroita, T, Matsumura, H, Yokota, N, Hashimoto, H, Imanaka, T, Inoue, T, Kai, Y.
Deposit date:2004-07-28
Release date:2005-08-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Mechanism for Coordination of Proofreading and Polymerase Activities in Archaeal DNA Polymerases
J.Mol.Biol., 351, 2005
4XZG
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BU of 4xzg by Molmil
Crystal structure of HIRAN domain of human HLTF
Descriptor: Helicase-like transcription factor
Authors:Ikegaya, Y, Hara, K, Hashimoto, H.
Deposit date:2015-02-04
Release date:2015-04-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
4XZF
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BU of 4xzf by Molmil
Crystal structure of HIRAN domain of human HLTF in complex with DNA
Descriptor: (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor
Authors:Hishiki, A, Hashimoto, H.
Deposit date:2015-02-04
Release date:2015-04-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
5EYO
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BU of 5eyo by Molmil
The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA
Descriptor: DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max
Authors:Wang, D, Hashimoto, H, Zhang, X, Cheng, X.
Deposit date:2015-11-25
Release date:2016-12-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
Nucleic Acids Res., 45, 2017
6J8Y
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BU of 6j8y by Molmil
Crystal structure of the human RAD9-HUS1-RAD1-RHINO complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ...
Authors:Hara, K, Iida, N, Sakurai, H, Hashimoto, H.
Deposit date:2019-01-21
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.
J.Biol.Chem., 295, 2020
5H6N
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BU of 5h6n by Molmil
DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form
Descriptor: Pierisin-1
Authors:Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
Deposit date:2016-11-14
Release date:2017-08-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
5H6J
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BU of 5h6j by Molmil
DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1
Authors:Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M.
Deposit date:2016-11-14
Release date:2017-08-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017

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