3WGW

Structure of PCNA bound to a small molecule inhibitor

Summary for 3WGW

Entry DOI	10.2210/pdb3wgw/pdb
Descriptor	Proliferating cell nuclear antigen, 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, SULFATE ION, ... (4 entities in total)
Functional Keywords	dna binding, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	59316.91
Authors	Hashimoto, H. (deposition date: 2013-08-12, release date: 2014-02-05, Last modification date: 2023-11-08)
Primary citation	Inoue, A.,Kikuchi, S.,Hishiki, A.,Shao, Y.,Heath, R.,Evison, B.J.,Actis, M.,Canman, C.E.,Hashimoto, H.,Fujii, N. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289:7109-7120, 2014 Cited by PubMed: 24474685 DOI: 10.1074/jbc.M113.520429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation