7V5N
 
 | | Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*GP*TP*TP*GP*GP*TP*GP*GP*TP*AP*GP*TP*TP*AP*CP*GP*TP*TP*CP*GP*C)-3'), IMIDAZOLE, ... | | Authors: | Hishiki, A, Tong, J, Todoroki, K, Hashimoto, H. | | Deposit date: | 2021-08-17 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.
Biosens.Bioelectron., 203, 2022
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7YBD
 | | Crystal structure of sliding DNA clamp of Clostridioides difficile | | Descriptor: | Beta sliding clamp, TRIETHYLENE GLYCOL | | Authors: | Hishiki, A, Okazaki, S, Hara, K, Hashimoto, H. | | Deposit date: | 2022-06-29 | | Release date: | 2022-10-19 | | Last modified: | 2023-01-11 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile.
J.Biochem., 173, 2022
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4XZF
 | | Crystal structure of HIRAN domain of human HLTF in complex with DNA | | Descriptor: | (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor | | Authors: | Hishiki, A, Hashimoto, H. | | Deposit date: | 2015-02-04 | | Release date: | 2015-04-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
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6KCS
 | | Crystal structure of HIRAN domain of HLTF in complex with duplex DNA | | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*GP*T)-3'), Helicase-like transcription factor | | Authors: | Hishiki, A, Hashimoto, A. | | Deposit date: | 2019-06-28 | | Release date: | 2020-06-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.
J.Biochem., 167, 2020
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2ZVL
 | | Crystal structure of PCNA in complex with DNA polymerase kappa fragment | | Descriptor: | DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ... | | Authors: | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | | Deposit date: | 2008-11-11 | | Release date: | 2009-02-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
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2ZVK
 | | Crystal structure of PCNA in complex with DNA polymerase eta fragment | | Descriptor: | DNA polymerase eta, Proliferating cell nuclear antigen | | Authors: | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | | Deposit date: | 2008-11-11 | | Release date: | 2009-02-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
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2ZVM
 | | Crystal structure of PCNA in complex with DNA polymerase iota fragment | | Descriptor: | DNA polymerase iota, Proliferating cell nuclear antigen | | Authors: | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | | Deposit date: | 2008-11-11 | | Release date: | 2009-02-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
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3B0T
 | | Human VDR ligand binding domain in complex with maxacalcitol | | Descriptor: | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor | | Authors: | Hishiki, A, Hashimoto, H, Sato, M, Shimizu, T. | | Deposit date: | 2011-06-14 | | Release date: | 2011-08-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Human VDR ligand binding domain in complex with maxacalcitol
To be Published
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3ALR
 | | Crystal structure of Nanos | | Descriptor: | Nanos protein, ZINC ION | | Authors: | Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M. | | Deposit date: | 2010-08-06 | | Release date: | 2011-02-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of zinc-finger domain of Nanos and its functional implications
Embo Rep., 11, 2010
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3VKX
 | | Structure of PCNA | | Descriptor: | 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ... | | Authors: | Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N. | | Deposit date: | 2011-11-26 | | Release date: | 2012-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
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3W08
 | | Crystal structure of aldoxime dehydratase | | Descriptor: | Aldoxime dehydratase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Hashimoto, H, Nomura, J, Hashimoto, Y, Oinuma, K.I, Wada, K, Hishiki, A, Hara, K, Kobayashi, M. | | Deposit date: | 2012-10-24 | | Release date: | 2013-02-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
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