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1PB7
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH GLYCINE AT 1.35 ANGSTROMS RESOLUTION
分子名称: GLYCINE, N-methyl-D-aspartate Receptor Subunit 1
著者Furukawa, H, Gouaux, E.
登録日2003-05-14
公開日2003-06-24
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB8
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION
分子名称: D-SERINE, N-methyl-D-aspartate Receptor Subunit 1
著者Furukawa, H, Gouaux, E.
登録日2003-05-14
公開日2003-06-24
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB9
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION
分子名称: (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, N-methyl-D-aspartate Receptor Subunit 1
著者Furukawa, H, Gouaux, E.
登録日2003-05-14
公開日2003-06-24
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PBQ
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CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION
分子名称: 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, N-methyl-D-aspartate Receptor Subunit 1
著者Furukawa, H, Gouaux, E.
登録日2003-05-14
公開日2003-07-29
最終更新日2020-07-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
分子名称: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
著者Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
登録日2005-06-30
公開日2005-11-15
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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Crystal Structure Of The NR1/NR2A ligand-binding cores complex
分子名称: GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ...
著者Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
登録日2005-06-30
公開日2005-11-15
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
6CNA
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BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Furukawa, H, Grant, T, Grigorieff, N.
登録日2018-03-07
公開日2018-10-03
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
8USX
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BU of 8usx by Molmil
Glycine-bound GluN1a-3A NMDA receptor
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
著者Michalski, K, Furukawa, H.
登録日2023-10-30
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8UUE
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Glycine-bound GluN1a-3A LBD heterotetramer (local refinement)
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
著者Michalski, K, Furukawa, H.
登録日2023-11-01
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8USW
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CNQX-bound GluN1a-3A NMDA receptor
分子名称: 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, Glutamate receptor ionotropic, NMDA 1, ...
著者Michalski, K, Furukawa, H.
登録日2023-10-30
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (4.23 Å)
主引用文献Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8E96
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Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ...
著者Kang, H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E99
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Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (4.24 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E97
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PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (4.19 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E94
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PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E98
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E92
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E93
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8S8Z
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Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
著者Syrjanen, J.L, Furukawa, H.
登録日2023-03-27
公開日2023-07-26
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
Nat Commun, 14, 2023
8S90
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Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
分子名称: Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
著者Syrjanen, J.L, Furukawa, H.
登録日2023-03-27
公開日2023-07-26
実験手法ELECTRON MICROSCOPY (4.73 Å)
主引用文献Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
Nat Commun, 14, 2023
2QTS
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BU of 2qts by Molmil
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ...
著者Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E.
登録日2007-08-02
公開日2007-09-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
7SAC
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S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution
分子名称: (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chou, T.-H, Furukawa, H.
登録日2021-09-22
公開日2022-07-20
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAA
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Glycine and glutamate bound GluN1a-GluN2B NMDA receptors in non-active 1 conformation at 2.97 Angstrom resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
著者Chou, T.-H, Furukawa, H.
登録日2021-09-22
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAD
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Memantine-bound GluN1a-GluN2B NMDA receptors
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2021-09-22
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAB
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Phencyclidine-bound GluN1a-GluN2B NMDA receptors
分子名称: 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chou, T.-H, Furukawa, H.
登録日2021-09-22
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
8G18
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Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Regan, M.C, Furukawa, H.
登録日2023-02-01
公開日2023-03-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Acs Chem Neurosci, 14, 2023

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