3HHR
 
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1TPK
 | | CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION | | 分子名称: | CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR | | 著者 | De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A. | | 登録日 | 1991-09-24 | | 公開日 | 1992-07-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
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1A22
 | | HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR | | 分子名称: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR | | 著者 | De Vos, A.M, Ultsch, M. | | 登録日 | 1998-01-15 | | 公開日 | 1998-04-29 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
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2VPF
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1AXI
 | | STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE | | 分子名称: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION | | 著者 | Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A. | | 登録日 | 1997-10-15 | | 公開日 | 1998-01-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
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1BHT
 | | NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR, SULFATE ION | | 著者 | Ultsch, M.H, Lokker, N.A, Godowski, P.J, De Vos, A.M. | | 登録日 | 1998-06-10 | | 公開日 | 1998-11-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Structure, 6, 1998
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1BP3
 | | THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX | | 分子名称: | PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION | | 著者 | Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A. | | 登録日 | 1998-08-12 | | 公開日 | 1998-08-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
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1BJ1
 | | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY | | 分子名称: | Fab fragment, heavy chain, light chain, ... | | 著者 | Muller, Y.A, Christinger, H.W, De Vos, A.M. | | 登録日 | 1998-06-30 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
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1A21
 | | TISSUE FACTOR (TF) FROM RABBIT | | 分子名称: | TISSUE FACTOR | | 著者 | Muller, Y.A, De Vos, A.M. | | 登録日 | 1998-01-14 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor.
Protein Sci., 7, 1998
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2HFT
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1VPF
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1S78
 | | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, ... | | 著者 | Franklin, M.C, Carey, K.D, Vajdos, F.F, Leahy, D.J, de Vos, A.M, Sliwkowski, M.X. | | 登録日 | 2004-01-29 | | 公開日 | 2004-04-27 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004
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1CZ8
 | | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | | 分子名称: | HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... | | 著者 | Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. | | 登録日 | 1999-09-01 | | 公開日 | 2000-03-20 | | 最終更新日 | 2017-04-05 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
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1QTY
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1RV6
 | | Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1 | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLT1 protein, placenta growth factor (PlGF) | | 著者 | Christinger, H.W, Fuh, G, de Vos, A.M, Wiesmann, C. | | 登録日 | 2003-12-12 | | 公開日 | 2004-01-20 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
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1F6F
 | | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | | 分子名称: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | | 著者 | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | | 登録日 | 2000-06-21 | | 公開日 | 2000-07-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
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1M1L
 | | Human Suppressor of Fused (N-terminal domain) | | 分子名称: | Suppressor of Fused | | 著者 | Merchant, M, Vajdos, F.F, Ultsch, M, Maun, H.R, Wendt, U, Cannon, J, Lazarus, R.A, de Vos, A.M, de Sauvage, F.J. | | 登録日 | 2002-06-19 | | 公開日 | 2004-02-03 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
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1VPP
 | | COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE | | 分子名称: | PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR) | | 著者 | Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M. | | 登録日 | 1998-10-09 | | 公開日 | 1999-02-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
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1WWB
 | | LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR | | 分子名称: | PROTEIN (Brain Derived Neurotrophic Factor Receptor TrkB) | | 著者 | Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M. | | 登録日 | 1999-05-03 | | 公開日 | 1999-07-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
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1WWW
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1WWC
 | | NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR | | 分子名称: | PROTEIN (NT-3 GROWTH FACTOR RECEPTOR TRKC) | | 著者 | Ultsch, M.H, Wiesmann, C, Simmons, L.C, Henrich, J, Yang, M, Reilly, D, Bass, S.H, De Vos, A.M. | | 登録日 | 1999-04-30 | | 公開日 | 1999-07-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
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1WWA
 | | NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR | | 分子名称: | PROTEIN (NERVE GROWTH FACTOR RECEPTOR TRKA) | | 著者 | Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M. | | 登録日 | 1999-04-29 | | 公開日 | 1999-07-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
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1OQX
 | | G-2 glycovariant of human IgG Fc bound to minimized version of Protein A called Z34C | | 分子名称: | Protein A Z34C, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H. | | 登録日 | 2003-03-11 | | 公開日 | 2003-03-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Impact of Fc Glycans on The Effector Functions Vary
with the Antibody mechanism of Action
To be Published
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1OQO
 | | Complex between G0 version of an Fc bound to a minimized version of Protein A called Mini-Z | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Minimized version of Protein A (Z34C), ... | | 著者 | Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H. | | 登録日 | 2003-03-10 | | 公開日 | 2003-03-20 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Impact of Fc Glycans on The Effector
Functions Vary with the Antibody
mechanism of Action
To be Published
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1QSV
 | | THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES | | 分子名称: | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 | | 著者 | Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J. | | 登録日 | 1999-06-23 | | 公開日 | 1999-11-10 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
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