6QCW
 
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6TU5
 | | Influenza A/H7N9 polymerase core (apo) | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Cusack, S, Pflug, A. | | Deposit date: | 2020-01-02 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.325 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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1H3F
 | | Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with tyrosinol | | Descriptor: | 4-[(2S)-2-amino-3-hydroxypropyl]phenol, SULFATE ION, TYROSYL-TRNA SYNTHETASE | | Authors: | Cusack, S, Yaremchuk, A, Kriklivyi, I, Tukalo, M. | | Deposit date: | 2002-08-28 | | Release date: | 2002-09-12 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Embo J., 21, 2002
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6F7J
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6F7S
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6F7P
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6F8D
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6FLN
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6FLM
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3ZJU
 | | Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3016 in the editing conformation | | Descriptor: | LEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, TRNALEU5 UAA ISOACCEPTOR | | Authors: | Cusack, S, Palencia, A, Crepin, T, Hernandez, V, Akama, T, Baker, S.J, Bu, W, Feng, L, Freund, Y.R, Liu, L, Meewan, M, Mohan, M, Mao, W, Rock, F.L, Sexton, H, Sheoran, A, Zhang, Y, Zhang, Y, Zhou, Y, Nieman, J.A, Anugula, M.R, Keramane, E.M, Savariraj, K, Reddy, D.S, Sharma, R, Subedi, R, Singh, R, OLeary, A, Simon, N.L, DeMarsh, P.L, Mushtaq, S, Warner, M, Livermore, D.M, Alley, M.R.K, Plattner, J.J. | | Deposit date: | 2013-01-18 | | Release date: | 2013-04-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
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3ZJV
 | | Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3213 in the editing conformation | | Descriptor: | LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR | | Authors: | Cusack, S, Palencia, A, Crepin, T, Hernandez, V, Akama, T, Baker, S.J, Bu, W, Feng, L, Freund, Y.R, Liu, L, Meewan, M, Mohan, M, Mao, W, Rock, F.L, Sexton, H, Sheoran, A, Zhang, Y, Zhang, Y, Zhou, Y, Nieman, J.A, Anugula, M.R, Keramane, E.M, Savariraj, K, Reddy, D.S, Sharma, R, Subedi, R, Singh, R, OLeary, A, Simon, N.L, DeMarsh, P.L, Mushtaq, S, Warner, M, Livermore, D.M, Alley, M.R.K, Plattner, J.J. | | Deposit date: | 2013-01-18 | | Release date: | 2013-04-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
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3ZJT
 | | Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the editing conformation | | Descriptor: | LEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, TRNALEU5 UAA ISOACCEPTOR | | Authors: | Cusack, S, Palencia, A, Crepin, T, Hernandez, V, Akama, T, Baker, S.J, Bu, W, Feng, L, Freund, Y.R, Liu, L, Meewan, M, Mohan, M, Mao, W, Rock, F.L, Sexton, H, Sheoran, A, Zhang, Y, Zhang, Y, Zhou, Y, Nieman, J.A, Anugula, M.R, Keramane, E.M, Savariraj, K, Reddy, D.S, Sharma, R, Subedi, R, Singh, R, OLeary, A, Simon, N.L, DeMarsh, P.L, Mushtaq, S, Warner, M, Livermore, D.M, Alley, M.R.K, Plattner, J.J. | | Deposit date: | 2013-01-18 | | Release date: | 2013-04-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
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4UYJ
 | | Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation | | Descriptor: | SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA | | Authors: | Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. | | Deposit date: | 2014-09-01 | | Release date: | 2014-11-05 | | Last modified: | 2014-12-03 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation.
RNA, 20, 2014
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4UYK
 | | Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation | | Descriptor: | SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA | | Authors: | Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. | | Deposit date: | 2014-09-01 | | Release date: | 2014-11-05 | | Last modified: | 2014-12-03 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation.
RNA, 20, 2014
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2V9T
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1914
 | | SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14 | | Descriptor: | BETA-MERCAPTOETHANOL, PHOSPHATE ION, SIGNAL RECOGNITION PARTICLE 9/14 FUSION PROTEIN | | Authors: | Birse, D, Kapp, U, Strub, K, Cusack, S, Aberg, A. | | Deposit date: | 1997-11-13 | | Release date: | 1998-12-30 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14.
EMBO J., 16, 1997
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4V4U
 | | The quasi-atomic model of Human Adenovirus type 5 capsid | | Descriptor: | HEXON PROTEIN, N-TERMINAL PEPTIDE OF FIBER PROTEIN, PENTON PROTEIN | | Authors: | Fabry, C.M.S, Rosa-Calatrava, M, Conway, J.F, Zubieta, C, Cusack, S, Ruigrok, R.W.H, Schoehn, G. | | Deposit date: | 2005-03-03 | | Release date: | 2014-07-09 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | A Quasi-Atomic Model of Human Adenovirus Type 5 Capsid.
Embo J., 24, 2005
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6Y6K
 | | Cryo-EM structure of a Phenuiviridae L protein | | Descriptor: | MAGNESIUM ION, RNA-dependent RNA polymerase | | Authors: | Vogel, D, Thorkelsson, S.R, Quemin, E, Meier, K, Kouba, T, Gogrefe, N, Busch, C, Reindl, S, Guenther, S, Cusack, S, Gruenewald, K, Rosenthal, M. | | Deposit date: | 2020-02-26 | | Release date: | 2020-04-08 | | Last modified: | 2020-06-10 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 48, 2020
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8R6U
 | | Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)] | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), RNA primer, ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription
BiorXiv, 2023
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8R6W
 | | Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING] | | Descriptor: | RNA (5'-R(*(M7G)*AP*AP*A)-3'), RNA (5'-R(*AP*CP*AP*C)-3'), RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription
BiorXiv, 2023
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8R6Y
 | | Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION] | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*(M7G)*AP*AP*A)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription
BiorXiv, 2023
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8BY6
 | | Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | | Authors: | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | | Deposit date: | 2022-12-12 | | Release date: | 2024-01-24 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
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1NSC
 | | INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, N-acetyl-alpha-neuraminic acid, ... | | Authors: | Burmeister, W.P, Ruigrok, R.W.H, Cusack, S. | | Deposit date: | 1993-05-24 | | Release date: | 1993-10-31 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Influenza B virus neuraminidase can synthesize its own inhibitor.
Structure, 1, 1993
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1NSD
 | | INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Burmeister, W.P, Ruigrok, R.W.H, Cusack, S. | | Deposit date: | 1993-05-24 | | Release date: | 1993-10-31 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Influenza B virus neuraminidase can synthesize its own inhibitor.
Structure, 1, 1993
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4WRT
 | | Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | | Descriptor: | Influenza virus polymerase vRNA promoter 3' end, Influenza virus polymerase vRNA promoter 5' end, PA, ... | | Authors: | Reich, S, Guilligay, D, Pflug, A, Cusack, S. | | Deposit date: | 2014-10-25 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
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