6FLN

Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains

Summary for 6FLN

Entry DOI	10.2210/pdb6fln/pdb
Related	4LTB 6FLM
Descriptor	E3 ubiquitin/ISG15 ligase TRIM25 (1 entity in total)
Functional Keywords	coiled-coil, pryspry domain, trim proteins, e3 ligase, protein binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q14258
Total number of polymer chains	3
Total formula weight	150865.45
Authors	Cusack, S.,Lethier, M. (deposition date: 2018-01-26, release date: 2018-05-23, Last modification date: 2024-01-17)
Primary citation	Koliopoulos, M.G.,Lethier, M.,van der Veen, A.G.,Haubrich, K.,Hennig, J.,Kowalinski, E.,Stevens, R.V.,Martin, S.R.,Reis E Sousa, C.,Cusack, S.,Rittinger, K. Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9:1820-1820, 2018 Cited by PubMed: 29739942 DOI: 10.1038/s41467-018-04214-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation