6FLM

Crystal structure of the human TRIM25 PRYSPRY domain

Summary for 6FLM

• Entry DOI: 10.2210/pdb6flm/pdb
• Descriptor: E3 ubiquitin/ISG15 ligase TRIM25, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: pryspry domain, trim protein, e3 ligase, protein binding
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q14258
• Total number of polymer chains: 3
• Total formula weight: 69369.84

Authors

Cusack, S.,Kowalinski, E. (deposition date: 2018-01-26, release date: 2018-05-23)

• Primary citation: Koliopoulos, M.G.,Lethier, M.,van der Veen, A.G.,Haubrich, K.,Hennig, J.,Kowalinski, E.,Stevens, R.V.,Martin, S.R.,Reis E Sousa, C.,Cusack, S.,Rittinger, K.; Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.; Nat Commun, 9:1820-1820, 2018; PubMed: 29739942; DOI: 10.1038/s41467-018-04214-8

Experimental method

X-RAY DIFFRACTION (2.009 Å)