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factor IXa superactive triple mutant, EDTA-soaked
Descriptor:	COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, D-PHE-PRO-ARG-CHLOROMETHYL KETONE
Authors:	Zogg, T, Brandstetter, H.
Deposit date:	2009-08-06
Release date:	2009-12-22
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.82 Å)
Cite:	Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009

4BTZ

Crystal Structure of peroxinitrite treated Major Birch Pollen Allergen Bet v 1.0101 (isoform a)
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A
Authors:	Kofler, S.G, Ackaert, C, Brandstetter, H.
Deposit date:	2013-06-19
Release date:	2014-07-02
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.47 Å)
Cite:	The Crystal Structure of the Major Birch Pollen Allergen Bet V 1 After Nitration with Peroxinitrite To be Published

6YSA

Crystal structure of Arabidopsis thaliana legumain isoform beta in zymogen state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SULFATE ION, ...
Authors:	Dall, E, Zauner, F.B, Brandstetter, H.
Deposit date:	2020-04-21
Release date:	2020-07-29
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	Structural and functional studies ofArabidopsis thalianalegumain beta reveal isoform specific mechanisms of activation and substrate recognition. J.Biol.Chem., 295, 2020

4FGU

Crystal structure of prolegumain
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain
Authors:	Dall, E, Brandstetter, H.
Deposit date:	2012-06-05
Release date:	2013-07-03
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.9 Å)
Cite:	Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc.Natl.Acad.Sci.USA, 110, 2013

4N6L

Crystal structure of human cystatin E/M
Descriptor:	Cystatin-M
Authors:	Dall, E, Brandstetter, H.
Deposit date:	2013-10-14
Release date:	2015-02-18
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.952 Å)
Cite:	Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew.Chem.Int.Ed.Engl., 54, 2015

4N1J

Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Descriptor:	GLYCEROL, NACHT, LRR and PYD domains-containing protein 14
Authors:	Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H.
Deposit date:	2013-10-04
Release date:	2014-07-16
Last modified:	2017-11-15
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014

5NIJ

Crystal structure of arabidopsis thaliana legumain isoform gamma in two-chain activation state
Descriptor:	CITRIC ACID, SULFATE ION, Vacuolar-processing enzyme gamma-isozyme
Authors:	Zauner, F.B, Dall, E, Brandstetter, H.
Deposit date:	2017-03-24
Release date:	2018-02-28
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation. Plant Cell, 30, 2018

5O7E

Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor
Descriptor:	CALCIUM ION, ColH protein, ZINC ION, ...
Authors:	Schoenauer, E, Brandstetter, H.
Deposit date:	2017-06-08
Release date:	2018-01-31
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.87 Å)
Cite:	Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J. Am. Chem. Soc., 139, 2017

5NZC

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
Descriptor:	Profilin-2
Authors:	Soh, W.T, Brandstetter, H.
Deposit date:	2017-05-12
Release date:	2017-10-25
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.999 Å)
Cite:	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5NZB

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
Descriptor:	Profilin-2
Authors:	Soh, W.T, Brandstetter, H.
Deposit date:	2017-05-12
Release date:	2017-10-25
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.695 Å)
Cite:	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5OBT

Fully activated A. thaliana legumain isoform gamma in complex with Ac-YVAD-CMK
Descriptor:	Ac-YVAD-CMK, Vacuolar-processing enzyme gamma-isozyme
Authors:	Zauner, B.F, Dall, E, Brandstetter, H.
Deposit date:	2017-06-29
Release date:	2018-04-11
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structural analyses ofArabidopsis thalianalegumain gamma reveal differential recognition and processing of proteolysis and ligation substrates. J. Biol. Chem., 293, 2018

5LUA

Crystal structure of human legumain (AEP) in complex with compound 11b
Descriptor:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LUB

Crystal structure of human legumain (AEP) in complex with compound 11
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LU8

CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LU9

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

2Y72

Crystal structure of the PKD Domain of Collagenase G from Clostridium Histolyticum at 1.18 Angstrom Resolution.
Descriptor:	COLLAGENASE
Authors:	Eckhard, U, Brandstetter, H.
Deposit date:	2011-01-27
Release date:	2011-09-28
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.18 Å)
Cite:	Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis Nat.Struct.Mol.Biol., 18, 2011

5JBB

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone
Descriptor:	CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
Authors:	Kristensen, L.H, Brandstetter, H.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.56 Å)
Cite:	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JB8

Crystal structure of factor IXa variant K98T in complex with EGR-chloromethylketone
Descriptor:	CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
Authors:	Kristensen, L.H, Brandstetter, H.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JBC

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with PPACK
Descriptor:	CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:	Kristensen, L.H, Brandstetter, H.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JBA

Crystal structure of factor IXa variant V16I K98T Y177T I212V in complex with PPACK
Descriptor:	CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:	Kristensen, L.H, Brandstetter, H.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

7O1U

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:	Dahms, S.O, Brandstetter, H.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O20

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:	Dahms, S.O, Brandstetter, H.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O22

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 4 (mi359)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:	Dahms, S.O, Brandstetter, H.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O1W

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:	Dahms, S.O, Brandstetter, H.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O1Y

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:	Dahms, S.O, Brandstetter, H.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

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