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5LU8

CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B

Summary for 5LU8
Entry DOI10.2210/pdb5lu8/pdb
Related PRD IDPRD_002086
DescriptorAC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, SULFATE ION, ... (7 entities in total)
Functional Keywordscysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight31754.30
Authors
Dall, E.,Ye, K.,Brandstetter, H. (deposition date: 2016-09-08, release date: 2017-03-29, Last modification date: 2024-01-17)
Primary citationZhang, Z.,Obianyo, O.,Dall, E.,Du, Y.,Fu, H.,Liu, X.,Kang, S.S.,Song, M.,Yu, S.P.,Cabrele, C.,Schubert, M.,Li, X.,Wang, J.Z.,Brandstetter, H.,Ye, K.
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8:14740-14740, 2017
Cited by
PubMed: 28345579
DOI: 10.1038/ncomms14740
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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