7O20

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)

Summary for 7O20

• Entry DOI: 10.2210/pdb7o20/pdb
• Descriptor: Furin, [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]methylidene]azanium, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: proprotein convertase, inhibitor, sars-cov-2, protease, complex, furin, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 53535.66

Authors

Dahms, S.O.,Brandstetter, H. (deposition date: 2021-03-30, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Dahms, S.O.,Haider, T.,Klebe, G.,Steinmetzer, T.,Brandstetter, H.; OFF-State-Specific Inhibition of the Proprotein Convertase Furin.; Acs Chem.Biol., 16:1692-1700, 2021; PubMed: 34415722; DOI: 10.1021/acschembio.1c00411

Experimental method

X-RAY DIFFRACTION (1.8 Å)