5LU9

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11

Summary for 5LU9

Entry DOI	10.2210/pdb5lu9/pdb
Related PRD ID	PRD_002086
Descriptor	AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	31481.54
Authors	Dall, E.,Ye, K.,Brandstetter, H. (deposition date: 2016-09-08, release date: 2017-03-29, Last modification date: 2024-01-17)
Primary citation	Zhang, Z.,Obianyo, O.,Dall, E.,Du, Y.,Fu, H.,Liu, X.,Kang, S.S.,Song, M.,Yu, S.P.,Cabrele, C.,Schubert, M.,Li, X.,Wang, J.Z.,Brandstetter, H.,Ye, K. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8:14740-14740, 2017 Cited by PubMed: 28345579 DOI: 10.1038/ncomms14740 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation