7O1U
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)
Summary for 7O1U
| Entry DOI | 10.2210/pdb7o1u/pdb |
| Descriptor | Furin, [[(2E)-2-[1-[3-[(E)-N-[[azaniumylidene(azanyl)methyl]amino]-C-methyl-carbonimidoyl]-5-azanyl-phenyl]ethylidene]hydrazinyl]-azanyl-methylidene]azanium, CALCIUM ION, ... (8 entities in total) |
| Functional Keywords | proprotein convertase, inhibitor, sars-cov-2, protease, complex, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 53185.05 |
| Authors | Dahms, S.O.,Brandstetter, H. (deposition date: 2021-03-30, release date: 2021-09-01, Last modification date: 2024-01-31) |
| Primary citation | Dahms, S.O.,Haider, T.,Klebe, G.,Steinmetzer, T.,Brandstetter, H. OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16:1692-1700, 2021 Cited by PubMed: 34415722DOI: 10.1021/acschembio.1c00411 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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