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factor IXa superactive triple mutant, EDTA-soaked
分子名称:	COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, D-PHE-PRO-ARG-CHLOROMETHYL KETONE
著者	Zogg, T, Brandstetter, H.
登録日	2009-08-06
公開日	2009-12-22
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.82 Å)
主引用文献	Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009

4BTZ

Crystal Structure of peroxinitrite treated Major Birch Pollen Allergen Bet v 1.0101 (isoform a)
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A
著者	Kofler, S.G, Ackaert, C, Brandstetter, H.
登録日	2013-06-19
公開日	2014-07-02
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.47 Å)
主引用文献	The Crystal Structure of the Major Birch Pollen Allergen Bet V 1 After Nitration with Peroxinitrite To be Published

6YSA

Crystal structure of Arabidopsis thaliana legumain isoform beta in zymogen state
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SULFATE ION, ...
著者	Dall, E, Zauner, F.B, Brandstetter, H.
登録日	2020-04-21
公開日	2020-07-29
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.01 Å)
主引用文献	Structural and functional studies ofArabidopsis thalianalegumain beta reveal isoform specific mechanisms of activation and substrate recognition. J.Biol.Chem., 295, 2020

4FGU

Crystal structure of prolegumain
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain
著者	Dall, E, Brandstetter, H.
登録日	2012-06-05
公開日	2013-07-03
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (3.9 Å)
主引用文献	Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc.Natl.Acad.Sci.USA, 110, 2013

4N6L

Crystal structure of human cystatin E/M
分子名称:	Cystatin-M
著者	Dall, E, Brandstetter, H.
登録日	2013-10-14
公開日	2015-02-18
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.952 Å)
主引用文献	Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew.Chem.Int.Ed.Engl., 54, 2015

4N1J

Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
分子名称:	GLYCEROL, NACHT, LRR and PYD domains-containing protein 14
著者	Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H.
登録日	2013-10-04
公開日	2014-07-16
最終更新日	2017-11-15
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014

5NIJ

Crystal structure of arabidopsis thaliana legumain isoform gamma in two-chain activation state
分子名称:	CITRIC ACID, SULFATE ION, Vacuolar-processing enzyme gamma-isozyme
著者	Zauner, F.B, Dall, E, Brandstetter, H.
登録日	2017-03-24
公開日	2018-02-28
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation. Plant Cell, 30, 2018

5O7E

Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor
分子名称:	CALCIUM ION, ColH protein, ZINC ION, ...
著者	Schoenauer, E, Brandstetter, H.
登録日	2017-06-08
公開日	2018-01-31
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.87 Å)
主引用文献	Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J. Am. Chem. Soc., 139, 2017

5NZC

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
分子名称:	Profilin-2
著者	Soh, W.T, Brandstetter, H.
登録日	2017-05-12
公開日	2017-10-25
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.999 Å)
主引用文献	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5NZB

A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2
分子名称:	Profilin-2
著者	Soh, W.T, Brandstetter, H.
登録日	2017-05-12
公開日	2017-10-25
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.695 Å)
主引用文献	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci, 18, 2017

5OBT

Fully activated A. thaliana legumain isoform gamma in complex with Ac-YVAD-CMK
分子名称:	Ac-YVAD-CMK, Vacuolar-processing enzyme gamma-isozyme
著者	Zauner, B.F, Dall, E, Brandstetter, H.
登録日	2017-06-29
公開日	2018-04-11
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Structural analyses ofArabidopsis thalianalegumain gamma reveal differential recognition and processing of proteolysis and ligation substrates. J. Biol. Chem., 293, 2018

5LUA

Crystal structure of human legumain (AEP) in complex with compound 11b
分子名称:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Dall, E, Ye, K, Brandstetter, H.
登録日	2016-09-08
公開日	2017-03-29
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LUB

Crystal structure of human legumain (AEP) in complex with compound 11
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, ...
著者	Dall, E, Ye, K, Brandstetter, H.
登録日	2016-09-08
公開日	2017-03-29
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LU8

CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
分子名称:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
著者	Dall, E, Ye, K, Brandstetter, H.
登録日	2016-09-08
公開日	2017-03-29
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LU9

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
著者	Dall, E, Ye, K, Brandstetter, H.
登録日	2016-09-08
公開日	2017-03-29
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.27 Å)
主引用文献	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

2Y72

Crystal structure of the PKD Domain of Collagenase G from Clostridium Histolyticum at 1.18 Angstrom Resolution.
分子名称:	COLLAGENASE
著者	Eckhard, U, Brandstetter, H.
登録日	2011-01-27
公開日	2011-09-28
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.18 Å)
主引用文献	Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis Nat.Struct.Mol.Biol., 18, 2011

5JBB

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone
分子名称:	CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
著者	Kristensen, L.H, Brandstetter, H.
登録日	2016-04-13
公開日	2016-06-01
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.56 Å)
主引用文献	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JB8

Crystal structure of factor IXa variant K98T in complex with EGR-chloromethylketone
分子名称:	CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
著者	Kristensen, L.H, Brandstetter, H.
登録日	2016-04-13
公開日	2016-06-01
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JBC

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with PPACK
分子名称:	CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
著者	Kristensen, L.H, Brandstetter, H.
登録日	2016-04-13
公開日	2016-06-01
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

5JBA

Crystal structure of factor IXa variant V16I K98T Y177T I212V in complex with PPACK
分子名称:	CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者	Kristensen, L.H, Brandstetter, H.
登録日	2016-04-13
公開日	2016-06-01
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016

7O1U

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Dahms, S.O, Brandstetter, H.
登録日	2021-03-30
公開日	2021-09-01
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O20

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Dahms, S.O, Brandstetter, H.
登録日	2021-03-30
公開日	2021-09-01
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O22

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 4 (mi359)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Dahms, S.O, Brandstetter, H.
登録日	2021-03-30
公開日	2021-09-01
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O1W

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Dahms, S.O, Brandstetter, H.
登録日	2021-03-30
公開日	2021-09-01
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

7O1Y

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者	Dahms, S.O, Brandstetter, H.
登録日	2021-03-30
公開日	2021-09-01
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021

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