7NVO
| Human TRiC complex in open state with nanobody bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
7NVN
| Human TRiC complex in closed state with nanobody and tubulin bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
4ZV6
| Crystal structure of the artificial alpharep-7 octarellinV.1 complex | Descriptor: | AlphaRep-7, Octarellin V.1 | Authors: | Figueroa, M, Sleutel, M, Urvoas, A, Valerio-Lepiniec, M, Minard, P, Martial, J.A, van de Weerdt, C. | Deposit date: | 2015-05-18 | Release date: | 2016-05-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools. J.Struct.Biol., 195, 2016
|
|
7SP8
| Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
|
|
7SP7
| Chlorella virus hyaluronan synthase inhibited by UDP | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
|
|
7SPA
| Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
|
|
7SP9
| Chlorella virus Hyaluronan Synthase in the GlcNAc-primed channel-closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
|
|
7SP6
| Chlorella virus hyaluronan synthase | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
|
|
8CQB
| |
6UKT
| Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex | Descriptor: | Guanine nucleotide-binding protein G(i) subunit alpha-1, NB8109, NB8117, ... | Authors: | Mou, T.C, Zhang, K, Johnston, J.D, Chiu, W, Sprang, S.R. | Deposit date: | 2019-10-05 | Release date: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1. Nat Commun, 11, 2020
|
|
6VI4
| Nanobody-Enabled Monitoring of Kappa Opioid Receptor States | Descriptor: | (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CHOLESTEROL, Kappa opioid receptor, ... | Authors: | Che, T, Roth, B.L. | Deposit date: | 2020-01-11 | Release date: | 2020-03-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Nanobody-enabled monitoring of kappa opioid receptor states. Nat Commun, 11, 2020
|
|
7GSP
| RIBONUCLEASE T1/2',3'-CGPS, NON-PRODUCTIVE | Descriptor: | GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, PHOSPHATE ION, RIBONUCLEASE T1 | Authors: | Zegers, I, Wyns, L. | Deposit date: | 1997-12-10 | Release date: | 1998-03-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. Nat.Struct.Biol., 5, 1998
|
|
3OSS
| The crystal structure of enterotoxigenic Escherichia coli GspC-GspD complex from the type II secretion system | Descriptor: | CALCIUM ION, CHLORIDE ION, TYPE 2 SECRETION SYSTEM, ... | Authors: | Korotkov, K.V, Pruneda, J, Hol, W.G.J. | Deposit date: | 2010-09-09 | Release date: | 2011-08-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. Plos Pathog., 7, 2011
|
|
8T60
| |
5VAN
| Crystal Structure of Beta-Klotho | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
5VAQ
| Crystal Structure of Beta-Klotho in Complex with FGF21CT | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
8E0G
| Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... | Authors: | Munro, T.A. | Deposit date: | 2022-08-09 | Release date: | 2023-10-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
|
|
7EH3
| |
5VAK
| Crystal Structure of Beta-Klotho, Domain 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
8FQ7
| Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7A17
| Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, GLYCEROL, Isoform 2 of Synaptojanin-1, ... | Authors: | Paesmans, J, Galicia, C, Martin, E, Versees, W. | Deposit date: | 2020-08-12 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations. Elife, 9, 2020
|
|
8QOT
| Structure of the mu opioid receptor bound to the antagonist nanobody NbE | Descriptor: | Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... | Authors: | Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. | Deposit date: | 2023-09-29 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist. Biorxiv, 2023
|
|
7A0V
| Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody | Descriptor: | GLYCEROL, MAGNESIUM ION, Nanobody 13015, ... | Authors: | Paesmans, J, Galicia, C, Martin, E, Versees, W. | Deposit date: | 2020-08-11 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations. Elife, 9, 2020
|
|
1RDS
| CRYSTAL STRUCTURE OF RIBONUCLEASE MS (AS RIBONUCLEASE T1 HOMOLOGUE) COMPLEXED WITH A GUANYLYL-3',5'-CYTIDINE ANALOGUE | Descriptor: | 2'-FLUOROGUANYLYL-(3'-5')-PHOSPHOCYTIDINE, RIBONUCLEASE MS | Authors: | Nonaka, T, Nakamura, K.T, Mitsui, Y. | Deposit date: | 1993-05-14 | Release date: | 1993-10-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of ribonuclease Ms (as a ribonuclease T1 homologue) complexed with a guanylyl-3',5'-cytidine analogue. Biochemistry, 32, 1993
|
|
6ZE1
| human NBD1 of CFTR in complex with nanobody G11a | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ... | Authors: | Garcia-Pino, A, Govaerts, C, Scholl, D, Sigoillot, M. | Deposit date: | 2020-06-15 | Release date: | 2021-06-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nat.Chem.Biol., 17, 2021
|
|