7NVN

Human TRiC complex in closed state with nanobody and tubulin bound

Summary for 7NVN

• Entry DOI: 10.2210/pdb7nvn/pdb
• EMDB information: 12605 12606 12607
• Descriptor: T-complex protein 1 subunit alpha, Tubulin beta-2A chain, ADENOSINE-5'-DIPHOSPHATE, ... (14 entities in total)
• Functional Keywords: tric, cct, atp hydrolysis, type ii chaperonin, protein folding, tubulin, chaperone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 19
• Total formula weight: 1034488.26

Authors

Kelly, J.J.,Chi, G.,Bulawa, C.,Paavilainen, V.O.,Bountra, C.,Huiskonen, J.T.,Yue, W. (deposition date: 2021-03-15, release date: 2022-03-02, Last modification date: 2022-06-01)

• Primary citation: Kelly, J.J.,Tranter, D.,Pardon, E.,Chi, G.,Kramer, H.,Happonen, L.,Knee, K.M.,Janz, J.M.,Steyaert, J.,Bulawa, C.,Paavilainen, V.O.,Huiskonen, J.T.,Yue, W.W.; Snapshots of actin and tubulin folding inside the TRiC chaperonin.; Nat.Struct.Mol.Biol., 29:420-429, 2022; PubMed: 35449234; DOI: 10.1038/s41594-022-00755-1

Experimental method

ELECTRON MICROSCOPY (3 Å)