7NVN
Human TRiC complex in closed state with nanobody and tubulin bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, J (A, a) | T-complex protein 1 subunit alpha | polymer | 556 | 60418.5 | 2 | UniProt (P17987) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-alpha,CCT-alpha |
| 2 | B, K (B, b) | T-complex protein 1 subunit beta | polymer | 535 | 57567.1 | 2 | UniProt (P78371) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-beta,CCT-beta |
| 3 | C, L (D, d) | T-complex protein 1 subunit delta | polymer | 539 | 57996.1 | 2 | UniProt (P50991) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-delta,CCT-delta,Stimulator of TAR RNA-binding |
| 4 | D, M (E, e) | T-complex protein 1 subunit epsilon | polymer | 541 | 59750.0 | 2 | UniProt (P48643) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-epsilon,CCT-epsilon |
| 5 | E, N (G, g) | T-complex protein 1 subunit gamma | polymer | 545 | 60613.9 | 2 | UniProt (P49368) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-gamma,CCT-gamma,hTRiC5 |
| 6 | F, O (H, h) | T-complex protein 1 subunit eta | polymer | 543 | 59443.5 | 2 | UniProt (Q99832) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-eta,CCT-eta,HIV-1 Nef-interacting protein |
| 7 | G, P (N, n) | Nanobody | polymer | 129 | 14412.8 | 2 | Lama glama | ||
| 8 | H, Q (Q, q) | T-complex protein 1 subunit theta | polymer | 548 | 59691.4 | 2 | UniProt (P50990) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-theta,CCT-theta,Chaperonin containing T-complex polypeptide 1 subunit 8,Renal carcinoma antigen NY-REN-15 |
| 9 | I, R (Z, z) | T-complex protein 1 subunit zeta | polymer | 531 | 58106.1 | 2 | UniProt (P40227) Pfam (PF00118) | Homo sapiens (Human) | TCP-1-zeta,Acute morphine dependence-related protein 2,CCT-zeta-1,HTR3,Tcp20 |
| 10 | S (T) | Tubulin beta-2A chain | polymer | 445 | 49921.7 | 1 | UniProt (Q13885) Pfam (PF00091) Pfam (PF03953) | Homo sapiens (Human) | Tubulin beta class IIa |
| 11 | AB, CA, DB, FA, GB... (e, E, g, G, h...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 16 | Chemie (ADP) | |||
| 12 | AA, BB, DA, EB, GA... (D, e, E, g, G...) | MAGNESIUM ION | non-polymer | 24.3 | 16 | Chemie (MG) | |||
| 13 | BA, CB, EA, FB, HA... (D, e, E, g, G...) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 16 | Chemie (AF3) | |||
| 14 | AC, BC, CC, DC, EC... (e, g, h, q, z...) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
T: 1 - 445 (UniProt: Q13885)
| PDB | External Database | Details |
|---|---|---|
| Val 170 | Met 170 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 19 |
| Total formula weight | 1025920.5 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 8567.7 | |
| All* | Total formula weight | 1034488.3 |
