2E9U
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![BU of 2e9u by Molmil](/molmil-images/mine/2e9u) | Structure of h-CHK1 complexed with A780125 | Descriptor: | 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE, Serine/threonine-protein kinase Chk1 | Authors: | Park, C. | Deposit date: | 2007-01-27 | Release date: | 2008-01-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors To be Published
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5WRV
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![BU of 5wrv by Molmil](/molmil-images/mine/5wrv) | Complex structure of human SRP72/SRP68 | Descriptor: | ACETATE ION, GLYCEROL, SODIUM ION, ... | Authors: | Gao, Y, Chen, Z. | Deposit date: | 2016-12-04 | Release date: | 2017-06-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation J Mol Cell Biol, 9, 2017
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6E40
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![BU of 6e40 by Molmil](/molmil-images/mine/6e40) | Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complexed with ferric heme and Epacadostat | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.306 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E42
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![BU of 6e42 by Molmil](/molmil-images/mine/6e42) | CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) in complex with ferric heme and 4-Chlorophenyl imidazole | Descriptor: | 4-(3-chlorophenyl)-1H-imidazole, Indoleamine 2,3-dioxygenase 1, PHOSPHATE ION, ... | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E41
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![BU of 6e41 by Molmil](/molmil-images/mine/6e41) | CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) in complex with ferric heme and an Epacadostat analog | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]sulfanyl}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.291 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E43
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![BU of 6e43 by Molmil](/molmil-images/mine/6e43) | Crystal structure of human indoleamine 2,3-dioxygenase 1 (IDO1) in complex with a BMS-978587 analog | Descriptor: | (1R,2S)-2-(4-[cyclohexyl(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, BENZOIC ACID, Indoleamine 2,3-dioxygenase 1 | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.705 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E45
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![BU of 6e45 by Molmil](/molmil-images/mine/6e45) | CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) free enzyme in the ferrous state | Descriptor: | GLYCEROL, Indoleamine 2,3-dioxygenase 1, PHOSPHATE ION, ... | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E44
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![BU of 6e44 by Molmil](/molmil-images/mine/6e44) | CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) free enzyme in the ferric state | Descriptor: | Indoleamine 2,3-dioxygenase 1, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6E46
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![BU of 6e46 by Molmil](/molmil-images/mine/6e46) | CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) in complex with ferrous heme and tryptophan | Descriptor: | Indoleamine 2,3-dioxygenase 1, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Luo, S, Tong, L. | Deposit date: | 2018-07-16 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74, 2018
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8I6U
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![BU of 8i6u by Molmil](/molmil-images/mine/8i6u) | The cryo-EM structure of OsCyc1 dimer state | Descriptor: | Syn-copalyl diphosphate synthase, chloroplastic | Authors: | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | Deposit date: | 2023-01-29 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8I6T
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![BU of 8i6t by Molmil](/molmil-images/mine/8i6t) | The cryo-EM structure of OsCyc1 hexamer state | Descriptor: | Syn-copalyl diphosphate synthase, chloroplastic | Authors: | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | Deposit date: | 2023-01-29 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8I6P
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![BU of 8i6p by Molmil](/molmil-images/mine/8i6p) | The cryo-EM structure of OsCyc1 tetramer state | Descriptor: | Syn-copalyl diphosphate synthase, chloroplastic | Authors: | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | Deposit date: | 2023-01-29 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8FH2
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![BU of 8fh2 by Molmil](/molmil-images/mine/8fh2) | |
8FGZ
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![BU of 8fgz by Molmil](/molmil-images/mine/8fgz) | |
8FH1
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![BU of 8fh1 by Molmil](/molmil-images/mine/8fh1) | |
8FH0
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![BU of 8fh0 by Molmil](/molmil-images/mine/8fh0) | |
8FGY
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![BU of 8fgy by Molmil](/molmil-images/mine/8fgy) | |
6SDA
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![BU of 6sda by Molmil](/molmil-images/mine/6sda) | Bd2924 C10 acyl-coenzymeA bound form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable acyl-CoA dehydrogenase, decanoyl-CoA | Authors: | Lovering, A.L, Harding, C.J. | Deposit date: | 2019-07-26 | Release date: | 2019-09-11 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins, 87, 2019
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6SD8
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![BU of 6sd8 by Molmil](/molmil-images/mine/6sd8) | Bd2924 apo-form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable acyl-CoA dehydrogenase | Authors: | Lovering, A.L, Harding, C.J. | Deposit date: | 2019-07-26 | Release date: | 2019-09-11 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins, 87, 2019
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4C13
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![BU of 4c13 by Molmil](/molmil-images/mine/4c13) | x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys | Descriptor: | CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. | Deposit date: | 2013-08-09 | Release date: | 2013-10-02 | Last modified: | 2021-03-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol., 2021
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8WZB
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![BU of 8wzb by Molmil](/molmil-images/mine/8wzb) | RS head-neck monomer | Descriptor: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | Authors: | Meng, X, Cong, Y. | Deposit date: | 2023-11-01 | Release date: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia. Nat Commun, 15, 2024
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8X2U
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![BU of 8x2u by Molmil](/molmil-images/mine/8x2u) | Radial spoke head-neck dimer | Descriptor: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | Authors: | Meng, X, Cong, Y. | Deposit date: | 2023-11-10 | Release date: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia. Nat Commun, 15, 2024
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5YMR
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![BU of 5ymr by Molmil](/molmil-images/mine/5ymr) | The Crystal Structure of IseG | Descriptor: | 2-hydroxyethylsulfonic acid, Formate acetyltransferase, GLYCEROL | Authors: | Lin, L, Zhang, J, Xing, M, Hua, G, Guo, C, Hu, Y, Wei, Y, Ang, E, Zhao, H, Zhang, Y, Yuchi, Z. | Deposit date: | 2017-10-22 | Release date: | 2019-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nat Commun, 10, 2019
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8J5Z
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![BU of 8j5z by Molmil](/molmil-images/mine/8j5z) | The cryo-EM structure of the TwOSC1 tetramer | Descriptor: | Terpene cyclase/mutase family member, octyl beta-D-glucopyranoside | Authors: | Ma, X, Yuru, T, Yunfeng, L, Jiang, T. | Deposit date: | 2023-04-24 | Release date: | 2023-11-01 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (4.75 Å) | Cite: | Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC. Angew.Chem.Int.Ed.Engl., 62, 2023
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5WRW
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![BU of 5wrw by Molmil](/molmil-images/mine/5wrw) | Structure of human apo-SRP72 | Descriptor: | SULFATE ION, Signal recognition particle subunit SRP72 | Authors: | Gao, Y, Chen, Z. | Deposit date: | 2016-12-04 | Release date: | 2017-06-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation J Mol Cell Biol, 9, 2017
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