2E9U

Structure of h-CHK1 complexed with A780125

Summary for 2E9U

• Entry DOI: 10.2210/pdb2e9u/pdb
• Related: 2AYP 2E9N 2E9O 2E9P 2E9V 2FGA 2GHG
• Descriptor: Serine/threonine-protein kinase Chk1, 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE (3 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 31417.53

Authors

Park, C. (deposition date: 2007-01-27, release date: 2008-01-29, Last modification date: 2024-03-13)

• Primary citation: Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gwaltney, S.L.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H.; Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)